The effect of short-term total parenteral nutrition on hepatic function in the human neonate

A prospective randomized study demonstrating alteration of hepatic canalicular function

Dennis Black, E. Amy Suttle, Peter F. Whitington, Gene L. Whitington, Sheldon D. Korones

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Twenty-one infants who were candidates for TPN because of respiratory disease were randomized into experimental (TPN) and control (glucose-electrolyte) groups. Serum GOT, GPT, GGTP, 5′ nucleotidase, total, direct, and conjugated (ethyl anthranilate-reactive) bilirubin, and bile salt concentrations were determined at entry into the study and at one week. One week of TPN caused significant elevations of GGTP, 5′-N, and EA bilirubin values, whereas SGOT, SGPT, SBS, and total and direct bilirubin were unaffected. Addition of a lipid infusion to TPN did not alter these differences. These data are interpreted as showing: (1) amino acid infusion has an early effect on hepatic function which is independent of the many diseases for which this therapy is used and of the concomitant use of lipid; (2) the initial effect appears to be on the canalicular membrane; and (3) the sinusoidal membrane is apparently unaffected by one week of TPN.

Original languageEnglish (US)
Pages (from-to)445-449
Number of pages5
JournalThe Journal of Pediatrics
Volume99
Issue number3
DOIs
StatePublished - Jan 1 1981

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Total Parenteral Nutrition
Bilirubin
gamma-Glutamyltransferase
Newborn Infant
Prospective Studies
Liver
Lipids
5'-Nucleotidase
Membranes
Aspartate Aminotransferases
Bile Acids and Salts
Alanine Transaminase
Electrolytes
Amino Acids
Glucose
Serum
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

The effect of short-term total parenteral nutrition on hepatic function in the human neonate : A prospective randomized study demonstrating alteration of hepatic canalicular function. / Black, Dennis; Suttle, E. Amy; Whitington, Peter F.; Whitington, Gene L.; Korones, Sheldon D.

In: The Journal of Pediatrics, Vol. 99, No. 3, 01.01.1981, p. 445-449.

Research output: Contribution to journalArticle

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