The effect of stimulant laxatives and polyethylene glycol-electrolyte lavage solution for colonoscopy preparation on serum electrolytes and hemodynamics

Virender K. Sharma, John W. Schaberg, Siva K. Chockalingam, Rajeev Vasudeva, Colin Howden

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We have previously shown that magnesium citrate or bisacodyl before polyethylene glycol electrolyte lavage solution (PEG-ELS) improves colonoscopy preparation. Patients prefer this to preparation with full-volume PEG-ELS alone. However, such combinations might cause undesirable changes in hemodynamics or serum electrolytes. This study examined the effects of these combinations on heart rate, blood pressure, and serum electrolytes. We randomized 68 consecutive patients undergoing colonoscopy to one of three preparations. Group 1 received 4 L of PEG-ELS, group 2 received 2 L of PEG-ELS with 20 mg bisacodyl, and group 3 received 2 L of PEG-ELS preceded by 296 mL of magnesium citrate. Heart rate, blood pressure, and serum electrolytes were measured before starting the preparation and immediately before colonoscopy. Mean serum magnesium fell by 0.01 mg/dL and 0.11 mg/dL in groups 1 and 2, respectively, and rose by 0.06 mg/dL in group 3 (p = 0.044). There were no other significant changes. Statistically significant changes in serum magnesium after preparation with PEG-ELS and a stimulant laxative are minor and probably of no clinical relevance. Two liters of PEG-ELS with a stimulant laxative is safe and effective for colonoscopy.

Original languageEnglish (US)
Pages (from-to)238-239
Number of pages2
JournalJournal of Clinical Gastroenterology
Volume32
Issue number3
DOIs
StatePublished - 2001
Externally publishedYes

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Laxatives
Therapeutic Irrigation
Colonoscopy
Electrolytes
Hemodynamics
Serum
Bisacodyl
Magnesium
Heart Rate
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

The effect of stimulant laxatives and polyethylene glycol-electrolyte lavage solution for colonoscopy preparation on serum electrolytes and hemodynamics. / Sharma, Virender K.; Schaberg, John W.; Chockalingam, Siva K.; Vasudeva, Rajeev; Howden, Colin.

In: Journal of Clinical Gastroenterology, Vol. 32, No. 3, 2001, p. 238-239.

Research output: Contribution to journalArticle

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