The effects of altitude on ex vivo perfusion of canine kidneys

Mitchell Goldman, Dennis R. French, Henry C. Langworthy, William H. Mints, Stephen B. Leapman

Research output: Contribution to journalArticle

Abstract

Thirteen mongrel dogs underwent bilateral nephrectomy and their kidneys were preserved by hypothermic pulsatile perfusion at various altitudes. With decreasing atmospheric pressure, perfusion pressures increased and pulse pressure decreased. At 400 Torr, reduction of gas volumes in the bubble trap and in the manometer line reduced systolic and diastolic pressures, but did not return pulse pressure to normal. Gas volume in the bubble trap increased with altitude and was great enough at 450-400 Torr to cause air embolization. Air emboli from the filter cap to both the oxygenator and the perfusion circuits were seen as well. No effect on creatinine, survival, or renal histology was demonstrated after autotransplantation in nine experimental dogs, as compared to three control dogs. Prevention of air emboli by the combination of gas expansion in the bubble trap and untoward movement during flight is possible by withdrawing gas from the bubble trap.

Original languageEnglish (US)
Pages (from-to)35-40
Number of pages6
JournalJournal of Surgical Research
Volume24
Issue number1
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

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Canidae
Perfusion
Gases
Blood Pressure
Kidney
Dogs
Embolism
Air
Air Filters
Oxygenators
Pulsatile Flow
Atmospheric Pressure
Autologous Transplantation
Nephrectomy
Creatinine
Histology
Pressure

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

The effects of altitude on ex vivo perfusion of canine kidneys. / Goldman, Mitchell; French, Dennis R.; Langworthy, Henry C.; Mints, William H.; Leapman, Stephen B.

In: Journal of Surgical Research, Vol. 24, No. 1, 01.01.1978, p. 35-40.

Research output: Contribution to journalArticle

Goldman, Mitchell ; French, Dennis R. ; Langworthy, Henry C. ; Mints, William H. ; Leapman, Stephen B. / The effects of altitude on ex vivo perfusion of canine kidneys. In: Journal of Surgical Research. 1978 ; Vol. 24, No. 1. pp. 35-40.
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