The effects of diltiazem in dystrophic hamsters

Syamal Bhattacharya, Genaro M.A. Palmieri, Tulio Bertorini, David F. Nutting

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Calcium accumulates in muscles of dystrophic hamsters (DH) and patients with Duchenne muscular dystrophy. Various Ca antagonists were beneficial to the cardiomyopathy of DH, but had only minor effects on skeletal muscle. We administered a new Ca antagonist, diltiazem, 25 mg/kg/day orally to normal and dystrophic hamsters from ages 37 to 92 days. We observed a marked reduction in muscle Ca in DH treated with diltiazem: 73% in the heart, 61% in the diaphragm, and 48% in the rectus femoris. Plasma CK was significantly lower (by 37%) in treated DH, while the elevated rate of noncollagen protein synthesis in the diaphragm was not diminished. Histologically, the most important change was a reduction in Ca deposits in the heart. Diltiazem was well‐tolerated by all animals and did not modify Ca content in normal hamsters. This study suggests that diltizem may have therapeutic value in those conditions that are accompanied by excessive accumulation of Ca in tissues, such as muscular dystrophy.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalMuscle & Nerve
Volume5
Issue number1
DOIs
StatePublished - Jan 1 1982

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Diltiazem
Cricetinae
Diaphragm
Muscles
Duchenne Muscular Dystrophy
Muscular Dystrophies
Quadriceps Muscle
Cardiomyopathies
Skeletal Muscle
Calcium
Proteins

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

The effects of diltiazem in dystrophic hamsters. / Bhattacharya, Syamal; Palmieri, Genaro M.A.; Bertorini, Tulio; Nutting, David F.

In: Muscle & Nerve, Vol. 5, No. 1, 01.01.1982, p. 73-78.

Research output: Contribution to journalArticle

Bhattacharya, Syamal ; Palmieri, Genaro M.A. ; Bertorini, Tulio ; Nutting, David F. / The effects of diltiazem in dystrophic hamsters. In: Muscle & Nerve. 1982 ; Vol. 5, No. 1. pp. 73-78.
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