The effects of ethanol upon threshold and response rate for self-stimulation

Richard H. Carlson, Ralph Lydic

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The hypothesis that ethanol would reduce the threshold for self-stimulation of the medial forebrain bundle was not supported. Ten rats, implanted with electrodes in the lateral hypothalamus, were shaped to bar press for electrical brain stimulation. The effects of 0.6, 0.9, and 1.2 g/kg ethanol injections upon threshold and response rate for self-stimulation were measured. The lowest dose had no effect upon self-stimulation threshold while 0.9 and 1.2 g/kg ethanol raised thresholds. Rate of bar pressing was increased by 0.6 g/kg ethanol but was not affected by higher dose. Results were discussed in terms of a postulated dual effect of ethanol upon a brain arousal system and upon a reward system.

Original languageEnglish (US)
Pages (from-to)61-64
Number of pages4
JournalPsychopharmacology
Volume50
Issue number1
DOIs
StatePublished - Jan 1 1976
Externally publishedYes

Fingerprint

Self Stimulation
Ethanol
Lateral Hypothalamic Area
Medial Forebrain Bundle
Implanted Electrodes
Deep Brain Stimulation
Arousal
Reward
Injections
Brain

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

The effects of ethanol upon threshold and response rate for self-stimulation. / Carlson, Richard H.; Lydic, Ralph.

In: Psychopharmacology, Vol. 50, No. 1, 01.01.1976, p. 61-64.

Research output: Contribution to journalArticle

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