The effects of in utero cocaine-exposure on the heart rate and heart rate variability of near and full term infants following orthostatic stress

Vijay John, Michael R. Neuman, Ajay Talati

Research output: Contribution to journalConference article

Abstract

To understand the effects of in utero cocaine exposure on the developing fetus, we studied the heart rate and the heart rate variability in near and full term cocaine-exposed infants in quiet sleep supine and following orthostatic stress. Methods: We studied 21 cocaine-exposed and 23 control infants within 120 hours of birth. Two 30-minute segments of the electrocardiogram (ECG) were recorded and analyzed in the time and frequency domain; the first with the supine infant, horizontal followed by the infant in a 25° head-up tilt. Results: The cocaine-exposed group, as compared with the control group, had a trend toward an increase in heart rate in the horizontal position and a significant increase in heart rate following the tilt in the cocaine-exposed group. The frequency components of the heart rate were lower in the horizontal position and increased following the orthostatic stress. Conclusions: These results are consistent with the known pharmacological actions of cocaine and demonstrate the dangers of cocaine abuse during pregnancy.

Original languageEnglish (US)
Pages (from-to)1626-1627
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

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Cocaine
Heart Rate
Cocaine-Related Disorders
Electrocardiography
Sleep
Fetus
Head
Parturition
Pharmacology
Pregnancy
Control Groups

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

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title = "The effects of in utero cocaine-exposure on the heart rate and heart rate variability of near and full term infants following orthostatic stress",
abstract = "To understand the effects of in utero cocaine exposure on the developing fetus, we studied the heart rate and the heart rate variability in near and full term cocaine-exposed infants in quiet sleep supine and following orthostatic stress. Methods: We studied 21 cocaine-exposed and 23 control infants within 120 hours of birth. Two 30-minute segments of the electrocardiogram (ECG) were recorded and analyzed in the time and frequency domain; the first with the supine infant, horizontal followed by the infant in a 25° head-up tilt. Results: The cocaine-exposed group, as compared with the control group, had a trend toward an increase in heart rate in the horizontal position and a significant increase in heart rate following the tilt in the cocaine-exposed group. The frequency components of the heart rate were lower in the horizontal position and increased following the orthostatic stress. Conclusions: These results are consistent with the known pharmacological actions of cocaine and demonstrate the dangers of cocaine abuse during pregnancy.",
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journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
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T1 - The effects of in utero cocaine-exposure on the heart rate and heart rate variability of near and full term infants following orthostatic stress

AU - John, Vijay

AU - Neuman, Michael R.

AU - Talati, Ajay

PY - 2002/12/1

Y1 - 2002/12/1

N2 - To understand the effects of in utero cocaine exposure on the developing fetus, we studied the heart rate and the heart rate variability in near and full term cocaine-exposed infants in quiet sleep supine and following orthostatic stress. Methods: We studied 21 cocaine-exposed and 23 control infants within 120 hours of birth. Two 30-minute segments of the electrocardiogram (ECG) were recorded and analyzed in the time and frequency domain; the first with the supine infant, horizontal followed by the infant in a 25° head-up tilt. Results: The cocaine-exposed group, as compared with the control group, had a trend toward an increase in heart rate in the horizontal position and a significant increase in heart rate following the tilt in the cocaine-exposed group. The frequency components of the heart rate were lower in the horizontal position and increased following the orthostatic stress. Conclusions: These results are consistent with the known pharmacological actions of cocaine and demonstrate the dangers of cocaine abuse during pregnancy.

AB - To understand the effects of in utero cocaine exposure on the developing fetus, we studied the heart rate and the heart rate variability in near and full term cocaine-exposed infants in quiet sleep supine and following orthostatic stress. Methods: We studied 21 cocaine-exposed and 23 control infants within 120 hours of birth. Two 30-minute segments of the electrocardiogram (ECG) were recorded and analyzed in the time and frequency domain; the first with the supine infant, horizontal followed by the infant in a 25° head-up tilt. Results: The cocaine-exposed group, as compared with the control group, had a trend toward an increase in heart rate in the horizontal position and a significant increase in heart rate following the tilt in the cocaine-exposed group. The frequency components of the heart rate were lower in the horizontal position and increased following the orthostatic stress. Conclusions: These results are consistent with the known pharmacological actions of cocaine and demonstrate the dangers of cocaine abuse during pregnancy.

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