The Effects of Indomethacin on the Pulmonary Vascular Response to Hypoxia in the Premature and Mature Newborn Goat

T. Tyler, R. Wallis, Charles Leffler, S. Cassin

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The effects of indomethacin on the pulmonary circulation and the response of the circulation to hypoxia were investigated in premature and mature newborns using an isolated perfusion technique on otherwise intact left lungs in situ. There was an increase in pulmonary vascular resistance and augmentation of the increase in pulmonary vascular resistance during hypoxia following indomethacin. These effects were greater in the premature than in the mature newborn. Indomethacin effectively removes a dilator influence on the pulmonary circulation. The results are consistent with the concept that prostaglandins are important in regulating pulmonary vascular resistance. The authors wish to thank N. L. Murtha, L. Tumarkin, M. Fradenburg, and T. Bendit for their technical assistance. This research was conducted under the guiding principles in the care and use of animals approved by the Council of the American Physiological Society and the National Institute of Health.

Original languageEnglish (US)
Pages (from-to)695-698
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume150
Issue number3
DOIs
StatePublished - Jan 1 1975

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Goats
Indomethacin
Vascular Resistance
Blood Vessels
Pulmonary Circulation
Lung
National Institutes of Health (U.S.)
Prostaglandins
Animals
Perfusion
Health
Research
Hypoxia

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The Effects of Indomethacin on the Pulmonary Vascular Response to Hypoxia in the Premature and Mature Newborn Goat. / Tyler, T.; Wallis, R.; Leffler, Charles; Cassin, S.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 150, No. 3, 01.01.1975, p. 695-698.

Research output: Contribution to journalArticle

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