The effects of omeprazole on endocrine function in man

A. J. MacGilchrist, Colin Howden, C. J. Kenyon, G. H. Beastall, J. L. Reid

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

We have assessed the effect of omeprazole on various endocrine functions in man. Eight healthy subjects took 60 mg omeprazole or placebo daily for 1 week in a double-blind, randomized, cross-over study. On Day 7 basal concentrations of follicle-stimulating hormone (FSH), luteinising hormone (LH), prolactin, testosterone, thyroid-stimulating hormone (TSH), and serum thyroxine (T4) and tri-iodothyronine (T3) were measured, followed by the gonadotrophin response to luteinising hormone releasing hormone (LHRH) and the prolactin and TSH responses to thyrotrophin releasing hormone (TRH). There were no differences in basal or stimulated values between omeprazole and placebo. In a second study, a further 8 subjects were similarly treated, and on Day 7 serial measurements of cortisol and 11-deoxycortisol were made before and for 2.5 h after intravenous adrenocorticotrophin (ACTH). There were no differences in basal values or pattern of response to ACTH for either hormone. Omeprazole in clinical practice is unlikely to cause any significant interference in endocrine function.

Original languageEnglish (US)
Pages (from-to)423-425
Number of pages3
JournalEuropean Journal of Clinical Pharmacology
Volume32
Issue number4
DOIs
StatePublished - Jul 1 1987
Externally publishedYes

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Omeprazole
Thyrotropin
Prolactin
Adrenocorticotropic Hormone
Placebos
Cortodoxone
Hormones
Follicle Stimulating Hormone
Luteinizing Hormone
Gonadotropins
Thyroxine
Gonadotropin-Releasing Hormone
Cross-Over Studies
Hydrocortisone
Testosterone
Healthy Volunteers
Serum

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

MacGilchrist, A. J., Howden, C., Kenyon, C. J., Beastall, G. H., & Reid, J. L. (1987). The effects of omeprazole on endocrine function in man. European Journal of Clinical Pharmacology, 32(4), 423-425. https://doi.org/10.1007/BF00543980

The effects of omeprazole on endocrine function in man. / MacGilchrist, A. J.; Howden, Colin; Kenyon, C. J.; Beastall, G. H.; Reid, J. L.

In: European Journal of Clinical Pharmacology, Vol. 32, No. 4, 01.07.1987, p. 423-425.

Research output: Contribution to journalArticle

MacGilchrist, AJ, Howden, C, Kenyon, CJ, Beastall, GH & Reid, JL 1987, 'The effects of omeprazole on endocrine function in man', European Journal of Clinical Pharmacology, vol. 32, no. 4, pp. 423-425. https://doi.org/10.1007/BF00543980
MacGilchrist, A. J. ; Howden, Colin ; Kenyon, C. J. ; Beastall, G. H. ; Reid, J. L. / The effects of omeprazole on endocrine function in man. In: European Journal of Clinical Pharmacology. 1987 ; Vol. 32, No. 4. pp. 423-425.
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