The ethnic/racial variations of intracerebral hemorrhage (ERICH) study protocol

Daniel Woo, Jonathan Rosand, Chelsea Kidwell, Jacob L. Mccauley, Jennifer Osborne, Mark W. Brown, Sandra E. West, Eric W. Rademacher, Salina Waddy, Jamie N. Roberts, Sebastian Koch, Nicole R. Gonzales, Gene Sung, Steven J. Kittner, Lee Birnbaum, Michael Frankel, Fernando Daniel Testai, Christiana E. Hall, Mitchell S.V. Elkind, Matthew Flaherty & 13 others Bruce Coull, Ji Y. Chong, Tanya Warwick, Marc Malkoff, Michael L. James, Latisha K. Ali, Bradford B. Worrall, Floyd Jones, Tiffany Watson, Anne Leonard, Rebecca Martinez, Ralph I. Sacco, Carl D. Langefeld

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background and Purpose-Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH. Methods-The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multi-center, prospective case- control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (±5 years), race, ethnicity, sex, and metropolitan region. Results-As of March 22, 2013, 1655 cases of ICH had been recruited into the study, which is 101.5% of the target for that date, and 851 controls had been recruited, which is 67.2% of the target for that date (1267 controls) for a total of 2506 subjects, which is 86.5% of the target for that date (2897 subjects). Of the 1655 cases enrolled, 1640 cases had the case interview entered into the database, of which 628 (38%) were non-Hispanic black, 458 (28%) were non-Hispanic white, and 554 (34%) were Hispanic. Of the 1197 cases with imaging submitted, 876 (73.2%) had a 24 hour follow-up CT available. In addition to CT imaging, 607 cases have had MRI evaluation. Conclusions-The ERICH study is a large, case-control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiological risk factors for ICH and outcomes after ICH.

Original languageEnglish (US)
JournalStroke
Volume44
Issue number10
DOIs
StatePublished - Oct 1 2013

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Cerebral Hemorrhage
Case-Control Studies
Hispanic Americans
Population Genetics
Neuroimaging
Epidemiologic Studies
Databases
Interviews
Phenotype
Incidence

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Woo, D., Rosand, J., Kidwell, C., Mccauley, J. L., Osborne, J., Brown, M. W., ... Langefeld, C. D. (2013). The ethnic/racial variations of intracerebral hemorrhage (ERICH) study protocol. Stroke, 44(10). https://doi.org/10.1161/STROKEAHA.113.002332

The ethnic/racial variations of intracerebral hemorrhage (ERICH) study protocol. / Woo, Daniel; Rosand, Jonathan; Kidwell, Chelsea; Mccauley, Jacob L.; Osborne, Jennifer; Brown, Mark W.; West, Sandra E.; Rademacher, Eric W.; Waddy, Salina; Roberts, Jamie N.; Koch, Sebastian; Gonzales, Nicole R.; Sung, Gene; Kittner, Steven J.; Birnbaum, Lee; Frankel, Michael; Testai, Fernando Daniel; Hall, Christiana E.; Elkind, Mitchell S.V.; Flaherty, Matthew; Coull, Bruce; Chong, Ji Y.; Warwick, Tanya; Malkoff, Marc; James, Michael L.; Ali, Latisha K.; Worrall, Bradford B.; Jones, Floyd; Watson, Tiffany; Leonard, Anne; Martinez, Rebecca; Sacco, Ralph I.; Langefeld, Carl D.

In: Stroke, Vol. 44, No. 10, 01.10.2013.

Research output: Contribution to journalArticle

Woo, D, Rosand, J, Kidwell, C, Mccauley, JL, Osborne, J, Brown, MW, West, SE, Rademacher, EW, Waddy, S, Roberts, JN, Koch, S, Gonzales, NR, Sung, G, Kittner, SJ, Birnbaum, L, Frankel, M, Testai, FD, Hall, CE, Elkind, MSV, Flaherty, M, Coull, B, Chong, JY, Warwick, T, Malkoff, M, James, ML, Ali, LK, Worrall, BB, Jones, F, Watson, T, Leonard, A, Martinez, R, Sacco, RI & Langefeld, CD 2013, 'The ethnic/racial variations of intracerebral hemorrhage (ERICH) study protocol', Stroke, vol. 44, no. 10. https://doi.org/10.1161/STROKEAHA.113.002332
Woo D, Rosand J, Kidwell C, Mccauley JL, Osborne J, Brown MW et al. The ethnic/racial variations of intracerebral hemorrhage (ERICH) study protocol. Stroke. 2013 Oct 1;44(10). https://doi.org/10.1161/STROKEAHA.113.002332
Woo, Daniel ; Rosand, Jonathan ; Kidwell, Chelsea ; Mccauley, Jacob L. ; Osborne, Jennifer ; Brown, Mark W. ; West, Sandra E. ; Rademacher, Eric W. ; Waddy, Salina ; Roberts, Jamie N. ; Koch, Sebastian ; Gonzales, Nicole R. ; Sung, Gene ; Kittner, Steven J. ; Birnbaum, Lee ; Frankel, Michael ; Testai, Fernando Daniel ; Hall, Christiana E. ; Elkind, Mitchell S.V. ; Flaherty, Matthew ; Coull, Bruce ; Chong, Ji Y. ; Warwick, Tanya ; Malkoff, Marc ; James, Michael L. ; Ali, Latisha K. ; Worrall, Bradford B. ; Jones, Floyd ; Watson, Tiffany ; Leonard, Anne ; Martinez, Rebecca ; Sacco, Ralph I. ; Langefeld, Carl D. / The ethnic/racial variations of intracerebral hemorrhage (ERICH) study protocol. In: Stroke. 2013 ; Vol. 44, No. 10.
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abstract = "Background and Purpose-Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH. Methods-The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multi-center, prospective case- control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (±5 years), race, ethnicity, sex, and metropolitan region. Results-As of March 22, 2013, 1655 cases of ICH had been recruited into the study, which is 101.5{\%} of the target for that date, and 851 controls had been recruited, which is 67.2{\%} of the target for that date (1267 controls) for a total of 2506 subjects, which is 86.5{\%} of the target for that date (2897 subjects). Of the 1655 cases enrolled, 1640 cases had the case interview entered into the database, of which 628 (38{\%}) were non-Hispanic black, 458 (28{\%}) were non-Hispanic white, and 554 (34{\%}) were Hispanic. Of the 1197 cases with imaging submitted, 876 (73.2{\%}) had a 24 hour follow-up CT available. In addition to CT imaging, 607 cases have had MRI evaluation. Conclusions-The ERICH study is a large, case-control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiological risk factors for ICH and outcomes after ICH.",
author = "Daniel Woo and Jonathan Rosand and Chelsea Kidwell and Mccauley, {Jacob L.} and Jennifer Osborne and Brown, {Mark W.} and West, {Sandra E.} and Rademacher, {Eric W.} and Salina Waddy and Roberts, {Jamie N.} and Sebastian Koch and Gonzales, {Nicole R.} and Gene Sung and Kittner, {Steven J.} and Lee Birnbaum and Michael Frankel and Testai, {Fernando Daniel} and Hall, {Christiana E.} and Elkind, {Mitchell S.V.} and Matthew Flaherty and Bruce Coull and Chong, {Ji Y.} and Tanya Warwick and Marc Malkoff and James, {Michael L.} and Ali, {Latisha K.} and Worrall, {Bradford B.} and Floyd Jones and Tiffany Watson and Anne Leonard and Rebecca Martinez and Sacco, {Ralph I.} and Langefeld, {Carl D.}",
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T1 - The ethnic/racial variations of intracerebral hemorrhage (ERICH) study protocol

AU - Woo, Daniel

AU - Rosand, Jonathan

AU - Kidwell, Chelsea

AU - Mccauley, Jacob L.

AU - Osborne, Jennifer

AU - Brown, Mark W.

AU - West, Sandra E.

AU - Rademacher, Eric W.

AU - Waddy, Salina

AU - Roberts, Jamie N.

AU - Koch, Sebastian

AU - Gonzales, Nicole R.

AU - Sung, Gene

AU - Kittner, Steven J.

AU - Birnbaum, Lee

AU - Frankel, Michael

AU - Testai, Fernando Daniel

AU - Hall, Christiana E.

AU - Elkind, Mitchell S.V.

AU - Flaherty, Matthew

AU - Coull, Bruce

AU - Chong, Ji Y.

AU - Warwick, Tanya

AU - Malkoff, Marc

AU - James, Michael L.

AU - Ali, Latisha K.

AU - Worrall, Bradford B.

AU - Jones, Floyd

AU - Watson, Tiffany

AU - Leonard, Anne

AU - Martinez, Rebecca

AU - Sacco, Ralph I.

AU - Langefeld, Carl D.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Background and Purpose-Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH. Methods-The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multi-center, prospective case- control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (±5 years), race, ethnicity, sex, and metropolitan region. Results-As of March 22, 2013, 1655 cases of ICH had been recruited into the study, which is 101.5% of the target for that date, and 851 controls had been recruited, which is 67.2% of the target for that date (1267 controls) for a total of 2506 subjects, which is 86.5% of the target for that date (2897 subjects). Of the 1655 cases enrolled, 1640 cases had the case interview entered into the database, of which 628 (38%) were non-Hispanic black, 458 (28%) were non-Hispanic white, and 554 (34%) were Hispanic. Of the 1197 cases with imaging submitted, 876 (73.2%) had a 24 hour follow-up CT available. In addition to CT imaging, 607 cases have had MRI evaluation. Conclusions-The ERICH study is a large, case-control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiological risk factors for ICH and outcomes after ICH.

AB - Background and Purpose-Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH. Methods-The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multi-center, prospective case- control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (±5 years), race, ethnicity, sex, and metropolitan region. Results-As of March 22, 2013, 1655 cases of ICH had been recruited into the study, which is 101.5% of the target for that date, and 851 controls had been recruited, which is 67.2% of the target for that date (1267 controls) for a total of 2506 subjects, which is 86.5% of the target for that date (2897 subjects). Of the 1655 cases enrolled, 1640 cases had the case interview entered into the database, of which 628 (38%) were non-Hispanic black, 458 (28%) were non-Hispanic white, and 554 (34%) were Hispanic. Of the 1197 cases with imaging submitted, 876 (73.2%) had a 24 hour follow-up CT available. In addition to CT imaging, 607 cases have had MRI evaluation. Conclusions-The ERICH study is a large, case-control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiological risk factors for ICH and outcomes after ICH.

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