The evolution of diabetic ketoacidosis

An update of its etiology, pathogenesis and management

Ebenezer Nyenwe, Abbas E. Kitabchi

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

The prognosis of diabetic ketoacidosis has undergone incredibly remarkable evolution since the discovery of insulin nearly a century ago. The incidence and economic burden of diabetic ketoacidosis have continued to rise but its mortality has decreased to less than 1% in good centers. Improved outcome is attributable to a better understanding of the pathophysiology of the disease and widespread application of treatment guidelines. In this review, we present the changes that have occurred over the years, highlighting the evidence behind the recommendations that have improved outcome. We begin with a discussion of the precipitants and pathogenesis of DKA as a prelude to understanding the rationale for the recommendations. A brief review of ketosis-prone type 2 diabetes, an update relating to the diagnosis of DKA and a future perspective are also provided.

Original languageEnglish (US)
Pages (from-to)507-521
Number of pages15
JournalMetabolism: clinical and experimental
Volume65
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Diabetic Ketoacidosis
Ketosis
Type 2 Diabetes Mellitus
Economics
Guidelines
Insulin
Mortality
Incidence

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

The evolution of diabetic ketoacidosis : An update of its etiology, pathogenesis and management. / Nyenwe, Ebenezer; Kitabchi, Abbas E.

In: Metabolism: clinical and experimental, Vol. 65, No. 4, 01.04.2016, p. 507-521.

Research output: Contribution to journalReview article

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