The fibroproliferative phase of late adult respiratory distress syndrome

Gianfranco Meduri, M. Eltorky, H. T. Winer-Muram

Research output: Contribution to journalReview article

45 Citations (Scopus)

Abstract

Tissue response to insults is similar regardless of the tissue involved, and occurs in two sequential and interconnected steps, inflammation and fibroproliferation. Adult respiratory distress syndrome (ARDS) is a disease characterized by acute onset of diffuse and severe inflammatory reaction of the lung parenchyma with loss of compartmentalization, resulting in protein rich exudative edema. Following tissue injury, a complex pattern of responses begins to repair the lung. Ineffective repair is evident histologically with extensive pulmonary fibroproliferation and clinically with fever (without a source of infection) and inability to improve lung function. We will review recent observations indicating that an exaggerated pulmonary inflammatory response plays a key role in the progression of ARDS. We will provide a unifying pathogenetic model of ARDS, showing how the evolution from acute to chronic inflammation explains the progression of histological, laboratory, clinical, and physiological findings seen during the course of unresolving ARDS.

Original languageEnglish (US)
Pages (from-to)154-175
Number of pages22
JournalSeminars in Respiratory Infections
Volume10
Issue number3
StatePublished - 1995

Fingerprint

Adult Respiratory Distress Syndrome
Lung
Inflammation
Acute Disease
Edema
Fever
Wounds and Injuries
Infection
Proteins

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pulmonary and Respiratory Medicine

Cite this

The fibroproliferative phase of late adult respiratory distress syndrome. / Meduri, Gianfranco; Eltorky, M.; Winer-Muram, H. T.

In: Seminars in Respiratory Infections, Vol. 10, No. 3, 1995, p. 154-175.

Research output: Contribution to journalReview article

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