The function of BAFF on T helper cells in autoimmunity

Maogen Chen, Xiaohong Lin, Ya Liu, Qiang Li, Yiling Deng, Zhongmin Liu, David Brand, Zhiyong Guo, Xiaoshun He, Bernhard Ryffel, Song Guo Zheng

Research output: Contribution to journalShort survey

18 Citations (Scopus)

Abstract

B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalCytokine and Growth Factor Reviews
Volume25
Issue number3
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Helper-Inducer T-Lymphocytes
Autoimmunity
B-Lymphocytes
Cells
T-cells
T-Lymphocytes
B-Cell Activating Factor
Hypergammaglobulinemia
Antigen-Antibody Complex
Autoantibodies
Genetic Recombination
Cell Differentiation
Chemical activation
Switches
Cell Proliferation

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Chen, M., Lin, X., Liu, Y., Li, Q., Deng, Y., Liu, Z., ... Zheng, S. G. (2014). The function of BAFF on T helper cells in autoimmunity. Cytokine and Growth Factor Reviews, 25(3), 301-305. https://doi.org/10.1016/j.cytogfr.2013.12.011

The function of BAFF on T helper cells in autoimmunity. / Chen, Maogen; Lin, Xiaohong; Liu, Ya; Li, Qiang; Deng, Yiling; Liu, Zhongmin; Brand, David; Guo, Zhiyong; He, Xiaoshun; Ryffel, Bernhard; Zheng, Song Guo.

In: Cytokine and Growth Factor Reviews, Vol. 25, No. 3, 01.01.2014, p. 301-305.

Research output: Contribution to journalShort survey

Chen, M, Lin, X, Liu, Y, Li, Q, Deng, Y, Liu, Z, Brand, D, Guo, Z, He, X, Ryffel, B & Zheng, SG 2014, 'The function of BAFF on T helper cells in autoimmunity', Cytokine and Growth Factor Reviews, vol. 25, no. 3, pp. 301-305. https://doi.org/10.1016/j.cytogfr.2013.12.011
Chen, Maogen ; Lin, Xiaohong ; Liu, Ya ; Li, Qiang ; Deng, Yiling ; Liu, Zhongmin ; Brand, David ; Guo, Zhiyong ; He, Xiaoshun ; Ryffel, Bernhard ; Zheng, Song Guo. / The function of BAFF on T helper cells in autoimmunity. In: Cytokine and Growth Factor Reviews. 2014 ; Vol. 25, No. 3. pp. 301-305.
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