The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization

Christina A. Cuomo, Ulrich Güldener, Jin Rong Xu, Frances Trail, B. Gillian Turgeon, Antonio Di Pietro, Jonathan D. Walton, Li Jun Ma, Scott E. Baker, Martijn Rep, Gerhard Adam, John Antoniw, Thomas Baldwin, Sarah Calvo, Yueh Long Chang, David DeCaprio, Liane R. Gale, Sante Gnerre, Rubella S. Goswami, Kim Hammond-Kosack & 25 others Linda J. Harris, Karen Hilburn, John C. Kennell, Scott Kroken, Jon K. Magnuson, Gertrud Mannhaupt, Evan Mauceli, Hans Werner Mewes, Rudolf Mitterbauer, Gary Muehlbauer, Martin Münsterkötter, David Nelson, Kerry O'Donnell, Thérèse Ouellet, Weihong Qi, Hadi Quesneville, M. Isabel G. Roncero, Kye Yong Seong, Igor V. Tetko, Martin Urban, Cees Waalwijk, Todd J. Ward, Jiqiang Yao, Bruce W. Birren, H. Corby Kistler

Research output: Contribution to journalArticle

512 Citations (Scopus)

Abstract

We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.

Original languageEnglish (US)
Pages (from-to)1400-1402
Number of pages3
JournalScience
Volume317
Issue number5843
DOIs
StatePublished - Sep 7 2007

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Fusarium
Fungi
Genome
Nucleic Acid Repetitive Sequences
Telomere
Point Mutation
Genetic Recombination
Genes
Single Nucleotide Polymorphism
Mutation
Edible Grain

All Science Journal Classification (ASJC) codes

  • General

Cite this

Cuomo, C. A., Güldener, U., Xu, J. R., Trail, F., Turgeon, B. G., Di Pietro, A., ... Kistler, H. C. (2007). The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. Science, 317(5843), 1400-1402. https://doi.org/10.1126/science.1143708

The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. / Cuomo, Christina A.; Güldener, Ulrich; Xu, Jin Rong; Trail, Frances; Turgeon, B. Gillian; Di Pietro, Antonio; Walton, Jonathan D.; Ma, Li Jun; Baker, Scott E.; Rep, Martijn; Adam, Gerhard; Antoniw, John; Baldwin, Thomas; Calvo, Sarah; Chang, Yueh Long; DeCaprio, David; Gale, Liane R.; Gnerre, Sante; Goswami, Rubella S.; Hammond-Kosack, Kim; Harris, Linda J.; Hilburn, Karen; Kennell, John C.; Kroken, Scott; Magnuson, Jon K.; Mannhaupt, Gertrud; Mauceli, Evan; Mewes, Hans Werner; Mitterbauer, Rudolf; Muehlbauer, Gary; Münsterkötter, Martin; Nelson, David; O'Donnell, Kerry; Ouellet, Thérèse; Qi, Weihong; Quesneville, Hadi; Roncero, M. Isabel G.; Seong, Kye Yong; Tetko, Igor V.; Urban, Martin; Waalwijk, Cees; Ward, Todd J.; Yao, Jiqiang; Birren, Bruce W.; Kistler, H. Corby.

In: Science, Vol. 317, No. 5843, 07.09.2007, p. 1400-1402.

Research output: Contribution to journalArticle

Cuomo, CA, Güldener, U, Xu, JR, Trail, F, Turgeon, BG, Di Pietro, A, Walton, JD, Ma, LJ, Baker, SE, Rep, M, Adam, G, Antoniw, J, Baldwin, T, Calvo, S, Chang, YL, DeCaprio, D, Gale, LR, Gnerre, S, Goswami, RS, Hammond-Kosack, K, Harris, LJ, Hilburn, K, Kennell, JC, Kroken, S, Magnuson, JK, Mannhaupt, G, Mauceli, E, Mewes, HW, Mitterbauer, R, Muehlbauer, G, Münsterkötter, M, Nelson, D, O'Donnell, K, Ouellet, T, Qi, W, Quesneville, H, Roncero, MIG, Seong, KY, Tetko, IV, Urban, M, Waalwijk, C, Ward, TJ, Yao, J, Birren, BW & Kistler, HC 2007, 'The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization', Science, vol. 317, no. 5843, pp. 1400-1402. https://doi.org/10.1126/science.1143708
Cuomo CA, Güldener U, Xu JR, Trail F, Turgeon BG, Di Pietro A et al. The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. Science. 2007 Sep 7;317(5843):1400-1402. https://doi.org/10.1126/science.1143708
Cuomo, Christina A. ; Güldener, Ulrich ; Xu, Jin Rong ; Trail, Frances ; Turgeon, B. Gillian ; Di Pietro, Antonio ; Walton, Jonathan D. ; Ma, Li Jun ; Baker, Scott E. ; Rep, Martijn ; Adam, Gerhard ; Antoniw, John ; Baldwin, Thomas ; Calvo, Sarah ; Chang, Yueh Long ; DeCaprio, David ; Gale, Liane R. ; Gnerre, Sante ; Goswami, Rubella S. ; Hammond-Kosack, Kim ; Harris, Linda J. ; Hilburn, Karen ; Kennell, John C. ; Kroken, Scott ; Magnuson, Jon K. ; Mannhaupt, Gertrud ; Mauceli, Evan ; Mewes, Hans Werner ; Mitterbauer, Rudolf ; Muehlbauer, Gary ; Münsterkötter, Martin ; Nelson, David ; O'Donnell, Kerry ; Ouellet, Thérèse ; Qi, Weihong ; Quesneville, Hadi ; Roncero, M. Isabel G. ; Seong, Kye Yong ; Tetko, Igor V. ; Urban, Martin ; Waalwijk, Cees ; Ward, Todd J. ; Yao, Jiqiang ; Birren, Bruce W. ; Kistler, H. Corby. / The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. In: Science. 2007 ; Vol. 317, No. 5843. pp. 1400-1402.
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AU - Cuomo, Christina A.

AU - Güldener, Ulrich

AU - Xu, Jin Rong

AU - Trail, Frances

AU - Turgeon, B. Gillian

AU - Di Pietro, Antonio

AU - Walton, Jonathan D.

AU - Ma, Li Jun

AU - Baker, Scott E.

AU - Rep, Martijn

AU - Adam, Gerhard

AU - Antoniw, John

AU - Baldwin, Thomas

AU - Calvo, Sarah

AU - Chang, Yueh Long

AU - DeCaprio, David

AU - Gale, Liane R.

AU - Gnerre, Sante

AU - Goswami, Rubella S.

AU - Hammond-Kosack, Kim

AU - Harris, Linda J.

AU - Hilburn, Karen

AU - Kennell, John C.

AU - Kroken, Scott

AU - Magnuson, Jon K.

AU - Mannhaupt, Gertrud

AU - Mauceli, Evan

AU - Mewes, Hans Werner

AU - Mitterbauer, Rudolf

AU - Muehlbauer, Gary

AU - Münsterkötter, Martin

AU - Nelson, David

AU - O'Donnell, Kerry

AU - Ouellet, Thérèse

AU - Qi, Weihong

AU - Quesneville, Hadi

AU - Roncero, M. Isabel G.

AU - Seong, Kye Yong

AU - Tetko, Igor V.

AU - Urban, Martin

AU - Waalwijk, Cees

AU - Ward, Todd J.

AU - Yao, Jiqiang

AU - Birren, Bruce W.

AU - Kistler, H. Corby

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