The High-Ethanol Preferring rat as a model to study the shift between alcohol abuse and dependence

Elena Terenina-Rigaldie, Byron Jones, Pierre Mormède

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The High-Ethanol Preferring line of rats (HEP), recently selected by R.D. Myers, is characterised by a high voluntary consumption of alcohol (3-4 g/kg/day for males and 6-8 g/kg/day for females, when a 10% ethanol solution is available as a choice vs. water) and a high sensitivity to taste reinforcement (saccharin, quinine). Our previous data obtained with HEP rats showed no evidence of development of dependence after long-term sustained alcohol intake. In this study, we subjected these rats to several long-term administration protocols suggested to favour the development of alcohol dependence, including multiple alcohol concentrations or sweetened alcohol solutions (ethanol 10% or 20%+saccharin), and deprivation periods. The results showed no increase in alcohol consumption, no shift of preference for alcohol solutions when offered as a free choice vs. a preferred saccharin solution, and a very limited alcohol-deprivation effect when alcohol is made available after a period of deprivation, the three criteria used to demonstrate the development of dependence. Regardless of the method used, HEP rats failed to show dependence after long-term, heavy ethanol consumption. Resistance to ethanol dependence may in fact be genetically influenced and the HEP rat appears as a valuable model to search for factors involved in the transition from alcohol abuse to dependence.

Original languageEnglish (US)
Pages (from-to)199-206
Number of pages8
JournalEuropean Journal of Pharmacology
Volume504
Issue number3
DOIs
StatePublished - Nov 19 2004
Externally publishedYes

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Alcoholism
Ethanol
Alcohols
Saccharin
Alcohol Drinking
Quinine
Water

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

The High-Ethanol Preferring rat as a model to study the shift between alcohol abuse and dependence. / Terenina-Rigaldie, Elena; Jones, Byron; Mormède, Pierre.

In: European Journal of Pharmacology, Vol. 504, No. 3, 19.11.2004, p. 199-206.

Research output: Contribution to journalArticle

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