The histologic differentiation of oral condyloma acuminatum from its mimics

Kenneth Anderson, Dehlia Perez-Montiel, Lili Miles, Carl M. Allen, Gerard J. Nuovo

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective. The purpose of this study was to determine which histologic features could enable one to distinguish oral condyloma, as defined by the detection of human papillomavirus (HPV) DNA through in situ hybridization, from its mimics. Study design. Thirty-two paraffin-embedded specimens from 28 patients that were clinically suggestive of oral condyloma were analyzed histologically and through in situ hybridization with a consensus HPV probe. Results. HPV DNA was detected in 17/32 (53%) of the lesions; no additional positive cases were detected after polymerase chain reaction amplification. Only 5 of the 17 virus-positive cases were considered to be histopathologically unequivocal for condyloma. The histologic features significantly associated with HPV detection were nonuniform perinuclear halos, often in association with epithelial crevices (P = .02), and papillomatosis (P = .02). Each of the 17 patients who were HPV-positive had either HPV-6 or HPV-11, a finding that is similar to those for condyloma involving the penis and vulva/vagina. Conclusion. Differentiation between oral condyloma and its mimics is best accomplished by using a combination of histologic, clinical, and in situ viral studies.

Original languageEnglish (US)
Pages (from-to)420-428
Number of pages9
JournalOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
Volume96
Issue number4
DOIs
StatePublished - Oct 1 2003
Externally publishedYes

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Condylomata Acuminata
In Situ Hybridization
Human papillomavirus 11
Human papillomavirus 6
Vulva
DNA
Penis
Papilloma
Vagina
Paraffin
Viruses
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology
  • Dentistry(all)

Cite this

The histologic differentiation of oral condyloma acuminatum from its mimics. / Anderson, Kenneth; Perez-Montiel, Dehlia; Miles, Lili; Allen, Carl M.; Nuovo, Gerard J.

In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, Vol. 96, No. 4, 01.10.2003, p. 420-428.

Research output: Contribution to journalArticle

Anderson, Kenneth ; Perez-Montiel, Dehlia ; Miles, Lili ; Allen, Carl M. ; Nuovo, Gerard J. / The histologic differentiation of oral condyloma acuminatum from its mimics. In: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 2003 ; Vol. 96, No. 4. pp. 420-428.
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