The human cationic amino acid transporter (ATRC1): Physical and genetic mapping to 13q12-q14

Lorraine Albritton, Anne M. Bowcock, Roger L. Eddy, Cynthia C. Morton, Lena Tseng, Lindsay A. Farrer, Luca L. Cavalli-Sforza, Thomas B. Shows, James M. Cunningham

Research output: Contribution to journalArticle

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Abstract

The product of the mouse Rec-1 locus is an integral membrane protein that determines susceptibility to infection by murine ecotropic retroviruses. Recently it has been determined that its role in normal cell metabolism is transport of the cationic amino acids, arginine, lysine, and ornithine across the plasma membrane. Southern blot analysis of genomic DNA from a panel of 48 mouse-human somatic cell hybrids assigned the human version of this gene, ATRC1, to chromosome 13. Chromosomal in situ hybridization localized the gene to 13q12-q14. A restriction fragment length polymorphism (RFLP) was detected with TaqI. There were two alleles with frequencies of 0.29 and 0.71. Pairwise linkage analysis established linkage between ATRC1 and ATP1AL1, D13S1, D13S6, D13S10, D13S11, D13S21, D13S22, D13S33, D13S36, and D13S37. Multilocus linkage analysis of five of the loci indicated that the most likely order of loci in this region was D13S11-ATP1AL1-ATRC1-D13S6-D13S33.

Original languageEnglish (US)
Pages (from-to)430-434
Number of pages5
JournalGenomics
Volume12
Issue number3
DOIs
StatePublished - Jan 1 1992

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Cationic Amino Acid Transporter 1
Basic Amino Acid Transport Systems
Physical Chromosome Mapping
Chromosomes, Human, Pair 13
Ornithine
Hybrid Cells
Retroviridae
Southern Blotting
Gene Frequency
Restriction Fragment Length Polymorphisms
Genes
Lysine
In Situ Hybridization
Arginine
Membrane Proteins
Cell Membrane
Amino Acids
DNA
Infection

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Albritton, L., Bowcock, A. M., Eddy, R. L., Morton, C. C., Tseng, L., Farrer, L. A., ... Cunningham, J. M. (1992). The human cationic amino acid transporter (ATRC1): Physical and genetic mapping to 13q12-q14. Genomics, 12(3), 430-434. https://doi.org/10.1016/0888-7543(92)90431-Q

The human cationic amino acid transporter (ATRC1) : Physical and genetic mapping to 13q12-q14. / Albritton, Lorraine; Bowcock, Anne M.; Eddy, Roger L.; Morton, Cynthia C.; Tseng, Lena; Farrer, Lindsay A.; Cavalli-Sforza, Luca L.; Shows, Thomas B.; Cunningham, James M.

In: Genomics, Vol. 12, No. 3, 01.01.1992, p. 430-434.

Research output: Contribution to journalArticle

Albritton, L, Bowcock, AM, Eddy, RL, Morton, CC, Tseng, L, Farrer, LA, Cavalli-Sforza, LL, Shows, TB & Cunningham, JM 1992, 'The human cationic amino acid transporter (ATRC1): Physical and genetic mapping to 13q12-q14', Genomics, vol. 12, no. 3, pp. 430-434. https://doi.org/10.1016/0888-7543(92)90431-Q
Albritton, Lorraine ; Bowcock, Anne M. ; Eddy, Roger L. ; Morton, Cynthia C. ; Tseng, Lena ; Farrer, Lindsay A. ; Cavalli-Sforza, Luca L. ; Shows, Thomas B. ; Cunningham, James M. / The human cationic amino acid transporter (ATRC1) : Physical and genetic mapping to 13q12-q14. In: Genomics. 1992 ; Vol. 12, No. 3. pp. 430-434.
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