The human red blood cell proteome and interactome

Steven Goodman, Anastasia Kurdia, Larry Ammann, David Kakhniashvili, Ovidiu Daescu

Research output: Contribution to journalShort survey

131 Citations (Scopus)

Abstract

The red blood cell or erythrocyte is easily purified, readily available, and has a relatively simple structure. Therefore, it has become a very well studied cell in terms of protein composition and function. RBC proteomic studies performed over the last five years, by several laboratories, have identified 751 proteins within the human erythrocyte. As RBCs contain few internal structures, the proteome will contain far fewer proteins than nucleated cells. In this minireview, we summarize the current knowledge of the RBC proteome, discuss alterations in this partial proteome in varied human disease states, and demonstrate how in silico studies of the RBC interactome can lead to considerable insight into disease diagnosis, severity, and drug or gene therapy response. To make these latter points we focus on what is known concerning changes in the RBC proteome in Sickle Cell Disease.

Original languageEnglish (US)
Pages (from-to)1391-1408
Number of pages18
JournalExperimental Biology and Medicine
Volume232
Issue number11
DOIs
StatePublished - Dec 1 2007

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Proteome
Blood
Erythrocytes
Cells
Drug therapy
Gene therapy
Proteins
Sickle Cell Anemia
Genetic Therapy
Computer Simulation
Proteomics
Drug Therapy
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Goodman, S., Kurdia, A., Ammann, L., Kakhniashvili, D., & Daescu, O. (2007). The human red blood cell proteome and interactome. Experimental Biology and Medicine, 232(11), 1391-1408. https://doi.org/10.3181/0706-MR-156

The human red blood cell proteome and interactome. / Goodman, Steven; Kurdia, Anastasia; Ammann, Larry; Kakhniashvili, David; Daescu, Ovidiu.

In: Experimental Biology and Medicine, Vol. 232, No. 11, 01.12.2007, p. 1391-1408.

Research output: Contribution to journalShort survey

Goodman, S, Kurdia, A, Ammann, L, Kakhniashvili, D & Daescu, O 2007, 'The human red blood cell proteome and interactome', Experimental Biology and Medicine, vol. 232, no. 11, pp. 1391-1408. https://doi.org/10.3181/0706-MR-156
Goodman, Steven ; Kurdia, Anastasia ; Ammann, Larry ; Kakhniashvili, David ; Daescu, Ovidiu. / The human red blood cell proteome and interactome. In: Experimental Biology and Medicine. 2007 ; Vol. 232, No. 11. pp. 1391-1408.
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