The impact of combined administration of paraquat and maneb on motor and non-motor functions in the rat

A. Tinakoua, Safa Bouabid, E. Faggiani, P. De Deurwaerdère, N. Lakhdar-Ghazal, A. Benazzouz

Research output: Contribution to journalArticle

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Abstract

Paraquat (PQ) and maneb (MB) are potential risk factors for Parkinson's disease. However, their impact on non-motor disorders, monoamine neurotransmission and basal ganglia function is not clearly determined. Here we investigated the effects of combined treatment with PQ/MB on motor behavior, anxiety and " depressive-like" disorders, tissue content of monoamines, and subthalamic nucleus (STN) neuronal activity. Male Sprague-Dawley rats were intoxicated by PQ (10 mg/kg) and MB (30 mg/kg) twice a week. Two weeks later, the majority of animals (group 1, 16/26) showed a severe loss of body weight with tremor and respiratory distress and others (group 2, 6/26) showed only tremor. Animals of group 2 received PQ/MB during four weeks before developing weight loss. A last group (group 3, 4/26) was insensitive to PQ/MB after 6 weeks of injections. Groups 1 and 2 displayed a failure of motor activity and motor coordination. Group 3 showed slight motor deficits only after the last injection of PQ/MB. Moreover, PQ/MB induced anxiety and " depressive-like" behaviors in animals of groups 2 and 3. Biochemical analysis showed that PQ/MB reduced striatal dopamine (DA) tissue content paralleled by changes in the activity of STN neurons without changing the content of norepinephrine and serotonin in the cortex. Our data provide evidence that individuals are not equally sensitive to PQ/MB and show that the motor deficits in vulnerable animals, are not only a result of DA neuron degeneration, but may also be a consequence of peripheral disabilities. Nevertheless, the parkinsonian-like non-motor impairments may be a direct consequence of the bilateral DA depletion.

Original languageEnglish (US)
Pages (from-to)118-129
Number of pages12
JournalNeuroscience
Volume311
DOIs
StatePublished - Jan 1 2015

Fingerprint

Maneb
Paraquat
Subthalamic Nucleus
Tremor
Dopamine
Anxiety
Corpus Striatum
Nerve Degeneration
Animal Behavior
Injections
Dopaminergic Neurons
Depressive Disorder
Basal Ganglia
Synaptic Transmission
Sprague Dawley Rats
Parkinson Disease
Weight Loss
Serotonin
Norepinephrine
Motor Activity

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

The impact of combined administration of paraquat and maneb on motor and non-motor functions in the rat. / Tinakoua, A.; Bouabid, Safa; Faggiani, E.; De Deurwaerdère, P.; Lakhdar-Ghazal, N.; Benazzouz, A.

In: Neuroscience, Vol. 311, 01.01.2015, p. 118-129.

Research output: Contribution to journalArticle

Tinakoua, A. ; Bouabid, Safa ; Faggiani, E. ; De Deurwaerdère, P. ; Lakhdar-Ghazal, N. ; Benazzouz, A. / The impact of combined administration of paraquat and maneb on motor and non-motor functions in the rat. In: Neuroscience. 2015 ; Vol. 311. pp. 118-129.
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