The importance of different murine cell types in the immunopotentiation produced by amphotericin methyl ester

Sidney Stein, Edeltraut J. Plut, Thomas E. Shine, J. Russell Little

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Amphotericin R (AmB) or its methyl ester (AME) are potent stimulants of humoral and cell-mediated immunity in mice. When AME is injected simultaneously with antigen, it augments humoral immunity by expansion of the primary as well as the memory B cell pool. The most consistent and dramatic effect of amphotericin on humoral immunity is the enhancement of secondary IgG responses. This effect on the IgM-IgG switch mechanism depends on T cells and is reduced following thymectomy on adult mice. The route and timing of amphotericin administration also have dramatic quantitative, effects on immunopotentiation. Neither polyclonal B cell activation nor stimulation of antigen uptake in vitro by peritoneal macrophages was observed following intraperitoneal injection of AME. A tentative hypothesis is that antigen-stimulated T cells are important sites of the immunostimulant effects of AME on murine immune responses.

Original languageEnglish (US)
Pages (from-to)211-221
Number of pages11
JournalCellular Immunology
Volume40
Issue number1
DOIs
StatePublished - Sep 15 1978
Externally publishedYes

Fingerprint

Amphotericin B
Esters
Humoral Immunity
Antigens
B-Lymphocytes
Immunoglobulin G
T-Lymphocytes
Immunologic Adjuvants
Thymectomy
Peritoneal Macrophages
Intraperitoneal Injections
Cellular Immunity
Immunoglobulin M
methylamphotericin B

All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

The importance of different murine cell types in the immunopotentiation produced by amphotericin methyl ester. / Stein, Sidney; Plut, Edeltraut J.; Shine, Thomas E.; Little, J. Russell.

In: Cellular Immunology, Vol. 40, No. 1, 15.09.1978, p. 211-221.

Research output: Contribution to journalArticle

Stein, Sidney ; Plut, Edeltraut J. ; Shine, Thomas E. ; Little, J. Russell. / The importance of different murine cell types in the immunopotentiation produced by amphotericin methyl ester. In: Cellular Immunology. 1978 ; Vol. 40, No. 1. pp. 211-221.
@article{cbb69c4a9a5645a98d0a9501bf2d955a,
title = "The importance of different murine cell types in the immunopotentiation produced by amphotericin methyl ester",
abstract = "Amphotericin R (AmB) or its methyl ester (AME) are potent stimulants of humoral and cell-mediated immunity in mice. When AME is injected simultaneously with antigen, it augments humoral immunity by expansion of the primary as well as the memory B cell pool. The most consistent and dramatic effect of amphotericin on humoral immunity is the enhancement of secondary IgG responses. This effect on the IgM-IgG switch mechanism depends on T cells and is reduced following thymectomy on adult mice. The route and timing of amphotericin administration also have dramatic quantitative, effects on immunopotentiation. Neither polyclonal B cell activation nor stimulation of antigen uptake in vitro by peritoneal macrophages was observed following intraperitoneal injection of AME. A tentative hypothesis is that antigen-stimulated T cells are important sites of the immunostimulant effects of AME on murine immune responses.",
author = "Sidney Stein and Plut, {Edeltraut J.} and Shine, {Thomas E.} and Little, {J. Russell}",
year = "1978",
month = "9",
day = "15",
doi = "10.1016/0008-8749(78)90328-3",
language = "English (US)",
volume = "40",
pages = "211--221",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - The importance of different murine cell types in the immunopotentiation produced by amphotericin methyl ester

AU - Stein, Sidney

AU - Plut, Edeltraut J.

AU - Shine, Thomas E.

AU - Little, J. Russell

PY - 1978/9/15

Y1 - 1978/9/15

N2 - Amphotericin R (AmB) or its methyl ester (AME) are potent stimulants of humoral and cell-mediated immunity in mice. When AME is injected simultaneously with antigen, it augments humoral immunity by expansion of the primary as well as the memory B cell pool. The most consistent and dramatic effect of amphotericin on humoral immunity is the enhancement of secondary IgG responses. This effect on the IgM-IgG switch mechanism depends on T cells and is reduced following thymectomy on adult mice. The route and timing of amphotericin administration also have dramatic quantitative, effects on immunopotentiation. Neither polyclonal B cell activation nor stimulation of antigen uptake in vitro by peritoneal macrophages was observed following intraperitoneal injection of AME. A tentative hypothesis is that antigen-stimulated T cells are important sites of the immunostimulant effects of AME on murine immune responses.

AB - Amphotericin R (AmB) or its methyl ester (AME) are potent stimulants of humoral and cell-mediated immunity in mice. When AME is injected simultaneously with antigen, it augments humoral immunity by expansion of the primary as well as the memory B cell pool. The most consistent and dramatic effect of amphotericin on humoral immunity is the enhancement of secondary IgG responses. This effect on the IgM-IgG switch mechanism depends on T cells and is reduced following thymectomy on adult mice. The route and timing of amphotericin administration also have dramatic quantitative, effects on immunopotentiation. Neither polyclonal B cell activation nor stimulation of antigen uptake in vitro by peritoneal macrophages was observed following intraperitoneal injection of AME. A tentative hypothesis is that antigen-stimulated T cells are important sites of the immunostimulant effects of AME on murine immune responses.

UR - http://www.scopus.com/inward/record.url?scp=0018163657&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018163657&partnerID=8YFLogxK

U2 - 10.1016/0008-8749(78)90328-3

DO - 10.1016/0008-8749(78)90328-3

M3 - Article

C2 - 359169

AN - SCOPUS:0018163657

VL - 40

SP - 211

EP - 221

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

IS - 1

ER -