The importance of thrombophilia in the treatment of Paget-Schroetter syndrome

David C. Cassada, Amy L. Lipscomb, Scott Stevens, Michael Freeman, Oscar Grandas, Mitchell Goldman

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Venous thoracic outlet syndrome (V-TOS) and associated subclavian vein thrombosis (SVT) result in significant patient morbidity and can be difficult to manage. Previous studies have suggested that both mechanical compressive factors and pathological alterations in patient coagulation may contribute to the development of SVT; however, no study has specifically evaluated the role of thrombophilia in the treatment of V-TOS and the need for long-term anticoagulation as an adjunct to surgical decompression. This retrospective study describes the clinical courses of 18 patients treated for V-TOS with and without acute SVT. In this review, 67% of patients with SVT are found to have relatively common coagulation disorders and 90% of postoperative complications were associated with some form of thrombophilia. This study suggests that thrombophilia may play an important role in the pathogenesis of V-TOS and may be a determinant of the success of surgical decompression. Clotting disorders should therefore be aggressively evaluated in this patient population and can improve therapeutic outcome.

Original languageEnglish (US)
Pages (from-to)596-601
Number of pages6
JournalAnnals of Vascular Surgery
Volume20
Issue number5
DOIs
StatePublished - Jan 1 2006

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Upper Extremity Deep Vein Thrombosis
Thrombophilia
Thoracic Outlet Syndrome
Subclavian Vein
Thrombosis
Surgical Decompression
Therapeutics
Retrospective Studies
Morbidity
Population

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

The importance of thrombophilia in the treatment of Paget-Schroetter syndrome. / Cassada, David C.; Lipscomb, Amy L.; Stevens, Scott; Freeman, Michael; Grandas, Oscar; Goldman, Mitchell.

In: Annals of Vascular Surgery, Vol. 20, No. 5, 01.01.2006, p. 596-601.

Research output: Contribution to journalArticle

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