The incidence of Kawasaki syndrome in West Coast health maintenance organizations

Ermias D. Belay, Robert C. Holman, Matthew J. Clarke, Frank De Stefano, Abtin Shahriari, Robert Davis, Philip H. Rhodes, Robert S. Thompson, Steven B. Black, Henry R. Shinefield, S. Michael Marcy, Joel I. Ward, John P. Mullooly, Robert T. Chen, Lawrence B. Schonberger

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Background. Kawasaki syndrome (KS) causes an acute vasculitis of unknown etiology. It is a leading cause of acquired heart disease of children in Japan and the United States. Methods. We examined the incidence of KS in a well-defined population group of children ≤6 years of age, using data collected through the Vaccine Safety Datalink (VSD) project. The VSD database contains information on >1 million children enrolled in four West Coast health maintenance organizations (HMOs). Results. During 1993 through 1996 a total of 234 physician-diagnosed KS patients were reported in the 4 HMOs; 152 (65.0%) were boys and 195 (83.3%) were <5 years of age. The incidence of KS among children <5 years of age in the HMOs ranged from 9.0 to 19.1 per 100 000 person years. KS incidence was higher among boys in 3 of the sites. In the 2 sites with the highest number of KS patients, a seasonal occurrence of KS in winter and early spring was observed. Overall 226 (96.6%) of the KS patients were reported to have been hospitalized; hospitalization rates for children <5 years of age ranged from 9.0 to 16.8 per 100 000 person years. Conclusions. The incidence of KS in the HMOs was similar to that reported in other population-based studies in the United States and higher than estimates for Australia and several European countries.

Original languageEnglish (US)
Pages (from-to)828-832
Number of pages5
JournalPediatric Infectious Disease Journal
Volume19
Issue number9
DOIs
StatePublished - Oct 5 2000
Externally publishedYes

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Mucocutaneous Lymph Node Syndrome
Health Maintenance Organizations
Incidence
Vaccines
Safety
Vasculitis
Population Groups
Heart Diseases
Japan
Hospitalization
Databases
Physicians

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Belay, E. D., Holman, R. C., Clarke, M. J., De Stefano, F., Shahriari, A., Davis, R., ... Schonberger, L. B. (2000). The incidence of Kawasaki syndrome in West Coast health maintenance organizations. Pediatric Infectious Disease Journal, 19(9), 828-832. https://doi.org/10.1097/00006454-200009000-00004

The incidence of Kawasaki syndrome in West Coast health maintenance organizations. / Belay, Ermias D.; Holman, Robert C.; Clarke, Matthew J.; De Stefano, Frank; Shahriari, Abtin; Davis, Robert; Rhodes, Philip H.; Thompson, Robert S.; Black, Steven B.; Shinefield, Henry R.; Marcy, S. Michael; Ward, Joel I.; Mullooly, John P.; Chen, Robert T.; Schonberger, Lawrence B.

In: Pediatric Infectious Disease Journal, Vol. 19, No. 9, 05.10.2000, p. 828-832.

Research output: Contribution to journalArticle

Belay, ED, Holman, RC, Clarke, MJ, De Stefano, F, Shahriari, A, Davis, R, Rhodes, PH, Thompson, RS, Black, SB, Shinefield, HR, Marcy, SM, Ward, JI, Mullooly, JP, Chen, RT & Schonberger, LB 2000, 'The incidence of Kawasaki syndrome in West Coast health maintenance organizations', Pediatric Infectious Disease Journal, vol. 19, no. 9, pp. 828-832. https://doi.org/10.1097/00006454-200009000-00004
Belay, Ermias D. ; Holman, Robert C. ; Clarke, Matthew J. ; De Stefano, Frank ; Shahriari, Abtin ; Davis, Robert ; Rhodes, Philip H. ; Thompson, Robert S. ; Black, Steven B. ; Shinefield, Henry R. ; Marcy, S. Michael ; Ward, Joel I. ; Mullooly, John P. ; Chen, Robert T. ; Schonberger, Lawrence B. / The incidence of Kawasaki syndrome in West Coast health maintenance organizations. In: Pediatric Infectious Disease Journal. 2000 ; Vol. 19, No. 9. pp. 828-832.
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abstract = "Background. Kawasaki syndrome (KS) causes an acute vasculitis of unknown etiology. It is a leading cause of acquired heart disease of children in Japan and the United States. Methods. We examined the incidence of KS in a well-defined population group of children ≤6 years of age, using data collected through the Vaccine Safety Datalink (VSD) project. The VSD database contains information on >1 million children enrolled in four West Coast health maintenance organizations (HMOs). Results. During 1993 through 1996 a total of 234 physician-diagnosed KS patients were reported in the 4 HMOs; 152 (65.0{\%}) were boys and 195 (83.3{\%}) were <5 years of age. The incidence of KS among children <5 years of age in the HMOs ranged from 9.0 to 19.1 per 100 000 person years. KS incidence was higher among boys in 3 of the sites. In the 2 sites with the highest number of KS patients, a seasonal occurrence of KS in winter and early spring was observed. Overall 226 (96.6{\%}) of the KS patients were reported to have been hospitalized; hospitalization rates for children <5 years of age ranged from 9.0 to 16.8 per 100 000 person years. Conclusions. The incidence of KS in the HMOs was similar to that reported in other population-based studies in the United States and higher than estimates for Australia and several European countries.",
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AU - Holman, Robert C.

AU - Clarke, Matthew J.

AU - De Stefano, Frank

AU - Shahriari, Abtin

AU - Davis, Robert

AU - Rhodes, Philip H.

AU - Thompson, Robert S.

AU - Black, Steven B.

AU - Shinefield, Henry R.

AU - Marcy, S. Michael

AU - Ward, Joel I.

AU - Mullooly, John P.

AU - Chen, Robert T.

AU - Schonberger, Lawrence B.

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