The influence of age upon inflammatory cell counts and structure of conjunctiva in chronic open‐angle glaucoma

David R. Gwynn, William C. Stewart, Hugh L. Hennis, Tod Mcmillan, Rebecca A. Pitts

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Abstract. We evaluated the influence of age upon conjunctival structure and number of inflammatory cells by studying perioperative conjunctival biopsies from 54 consecutive primary open‐angle glaucoma patients undergoing initial filtering surgery (trabeculectomy alone or combined cataract extraction and trabeculectomy). All patients had received chronic topical glaucoma therapy for >1 year. We divided the patients into three age groups for analysis: 40–60 (n = 10), 61–74 (n = 28), and > 75 (n = 16) years. We found no statistical difference (p > 0.05, chi‐square) in cell counts of neutrophils, eosinophils, mast cells, macrophages, fibroblasts, lymphocytes, plasma cells and goblet cells across the three age groups. In addition, no statistical differences were observed between age groups in vascular density, epithelial thickness as well as mucopolysaccharide and collagen composition (p > 0.05, chi square). This study suggests that conjunctival structure and inflammatory cell counts change little with advancing age in primary open‐angle glaucoma patients. 1993 Institution Acta Ophthalmologica Scandinavica

Original languageEnglish (US)
Pages (from-to)691-695
Number of pages5
JournalActa Ophthalmologica
Volume71
Issue number5
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

Fingerprint

Conjunctiva
Glaucoma
Cell Count
Trabeculectomy
Age Groups
Filtering Surgery
Goblet Cells
Cataract Extraction
Plasma Cells
Glycosaminoglycans
Eosinophils
Mast Cells
Blood Vessels
Neutrophils
Collagen
Fibroblasts
Macrophages
Lymphocytes
Biopsy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

The influence of age upon inflammatory cell counts and structure of conjunctiva in chronic open‐angle glaucoma. / Gwynn, David R.; Stewart, William C.; Hennis, Hugh L.; Mcmillan, Tod; Pitts, Rebecca A.

In: Acta Ophthalmologica, Vol. 71, No. 5, 01.01.1993, p. 691-695.

Research output: Contribution to journalArticle

Gwynn, David R. ; Stewart, William C. ; Hennis, Hugh L. ; Mcmillan, Tod ; Pitts, Rebecca A. / The influence of age upon inflammatory cell counts and structure of conjunctiva in chronic open‐angle glaucoma. In: Acta Ophthalmologica. 1993 ; Vol. 71, No. 5. pp. 691-695.
@article{fdc25645736e4ed49fc332f8d4b8a005,
title = "The influence of age upon inflammatory cell counts and structure of conjunctiva in chronic open‐angle glaucoma",
abstract = "Abstract. We evaluated the influence of age upon conjunctival structure and number of inflammatory cells by studying perioperative conjunctival biopsies from 54 consecutive primary open‐angle glaucoma patients undergoing initial filtering surgery (trabeculectomy alone or combined cataract extraction and trabeculectomy). All patients had received chronic topical glaucoma therapy for >1 year. We divided the patients into three age groups for analysis: 40–60 (n = 10), 61–74 (n = 28), and > 75 (n = 16) years. We found no statistical difference (p > 0.05, chi‐square) in cell counts of neutrophils, eosinophils, mast cells, macrophages, fibroblasts, lymphocytes, plasma cells and goblet cells across the three age groups. In addition, no statistical differences were observed between age groups in vascular density, epithelial thickness as well as mucopolysaccharide and collagen composition (p > 0.05, chi square). This study suggests that conjunctival structure and inflammatory cell counts change little with advancing age in primary open‐angle glaucoma patients. 1993 Institution Acta Ophthalmologica Scandinavica",
author = "Gwynn, {David R.} and Stewart, {William C.} and Hennis, {Hugh L.} and Tod Mcmillan and Pitts, {Rebecca A.}",
year = "1993",
month = "1",
day = "1",
doi = "10.1111/j.1755-3768.1993.tb04663.x",
language = "English (US)",
volume = "71",
pages = "691--695",
journal = "Acta Ophthalmologica",
issn = "1755-375X",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - The influence of age upon inflammatory cell counts and structure of conjunctiva in chronic open‐angle glaucoma

AU - Gwynn, David R.

AU - Stewart, William C.

AU - Hennis, Hugh L.

AU - Mcmillan, Tod

AU - Pitts, Rebecca A.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Abstract. We evaluated the influence of age upon conjunctival structure and number of inflammatory cells by studying perioperative conjunctival biopsies from 54 consecutive primary open‐angle glaucoma patients undergoing initial filtering surgery (trabeculectomy alone or combined cataract extraction and trabeculectomy). All patients had received chronic topical glaucoma therapy for >1 year. We divided the patients into three age groups for analysis: 40–60 (n = 10), 61–74 (n = 28), and > 75 (n = 16) years. We found no statistical difference (p > 0.05, chi‐square) in cell counts of neutrophils, eosinophils, mast cells, macrophages, fibroblasts, lymphocytes, plasma cells and goblet cells across the three age groups. In addition, no statistical differences were observed between age groups in vascular density, epithelial thickness as well as mucopolysaccharide and collagen composition (p > 0.05, chi square). This study suggests that conjunctival structure and inflammatory cell counts change little with advancing age in primary open‐angle glaucoma patients. 1993 Institution Acta Ophthalmologica Scandinavica

AB - Abstract. We evaluated the influence of age upon conjunctival structure and number of inflammatory cells by studying perioperative conjunctival biopsies from 54 consecutive primary open‐angle glaucoma patients undergoing initial filtering surgery (trabeculectomy alone or combined cataract extraction and trabeculectomy). All patients had received chronic topical glaucoma therapy for >1 year. We divided the patients into three age groups for analysis: 40–60 (n = 10), 61–74 (n = 28), and > 75 (n = 16) years. We found no statistical difference (p > 0.05, chi‐square) in cell counts of neutrophils, eosinophils, mast cells, macrophages, fibroblasts, lymphocytes, plasma cells and goblet cells across the three age groups. In addition, no statistical differences were observed between age groups in vascular density, epithelial thickness as well as mucopolysaccharide and collagen composition (p > 0.05, chi square). This study suggests that conjunctival structure and inflammatory cell counts change little with advancing age in primary open‐angle glaucoma patients. 1993 Institution Acta Ophthalmologica Scandinavica

UR - http://www.scopus.com/inward/record.url?scp=0027739817&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027739817&partnerID=8YFLogxK

U2 - 10.1111/j.1755-3768.1993.tb04663.x

DO - 10.1111/j.1755-3768.1993.tb04663.x

M3 - Article

VL - 71

SP - 691

EP - 695

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

IS - 5

ER -