Influenza dell'utilizzo di soluzioni antibiotiche sulle proprietà meccaniche di cementi endodontici

Translated title of the contribution: The influence of antibiotics on the physical properties of endodontic cements

M. A. Saghiri, A. Asatourian, J. Orangi, J. W. Soukup, J. L. Gutmann, Franklin Garcia-Godoy, N. Sheibani

Research output: Contribution to journalArticle

Abstract

Aim To evaluate the influence of Metronidazole, Minocycline and Ciprofloxacin as a mixture or individually and of chlorhexidine on the push-out bond strength and surface microhardness of calcium silicate cements of differing particle size. Methodology 120 extracted adult human premolars were decoronated and 2 mm dentin slices were prepared. Specimens were divided equally into the following groups: normal saline and CHX, Metronidazole, Minocycline, Ciprofloxacin, and combination of Metronidazole, Minocycline and Ciprofloxacin. The specimens were irrigated with solutions and filled with endodontic cements. In the second part, the endodontic cements were mixed, placed in plastic tubes and then irrigated for 1 or 5 min. Push-out and surface microhardness values were calculated and data were analyzed with three way ANOVA followed by Tukey's post-hoc test. Results The normal saline and ciprofloxacin groups showed significantly higher and lower, respectively, push-out bond strength among the experimental groups (p < 0.001 for all groups). Nano type cement showed higher push-out bond strength and microhardness than regular one at both time intervals. The mixture of antibiotics had significant effects on the push out and microhardness of calcium silicate cement. Conclusions Nano particle MTA resisted more than the conventional MTA to the effect of the irrigating solution and antibiotics in both hardness and push-out strength. Furthermore, the results of microhardness were consistent with the push-out strength in most cases. The microhardness test may be employed as a complimentary test to evaluate push-out strength of dental cements.

Original languageItalian
Pages (from-to)89-95
Number of pages7
JournalGiornale Italiano di Endodonzia
Volume30
Issue number2
DOIs
StatePublished - Nov 1 2016

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Endodontics
Ciprofloxacin
Minocycline
Pemetrexed
Metronidazole
Silicate Cement
Anti-Bacterial Agents
Dental Cements
Chlorhexidine
Bicuspid
Hardness
Dentin
Particle Size
Plastics
Analysis of Variance
calcium silicate

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Influenza dell'utilizzo di soluzioni antibiotiche sulle proprietà meccaniche di cementi endodontici. / Saghiri, M. A.; Asatourian, A.; Orangi, J.; Soukup, J. W.; Gutmann, J. L.; Garcia-Godoy, Franklin; Sheibani, N.

In: Giornale Italiano di Endodonzia, Vol. 30, No. 2, 01.11.2016, p. 89-95.

Research output: Contribution to journalArticle

Saghiri, M. A. ; Asatourian, A. ; Orangi, J. ; Soukup, J. W. ; Gutmann, J. L. ; Garcia-Godoy, Franklin ; Sheibani, N. / Influenza dell'utilizzo di soluzioni antibiotiche sulle proprietà meccaniche di cementi endodontici. In: Giornale Italiano di Endodonzia. 2016 ; Vol. 30, No. 2. pp. 89-95.
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AU - Gutmann, J. L.

AU - Garcia-Godoy, Franklin

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N2 - Aim To evaluate the influence of Metronidazole, Minocycline and Ciprofloxacin as a mixture or individually and of chlorhexidine on the push-out bond strength and surface microhardness of calcium silicate cements of differing particle size. Methodology 120 extracted adult human premolars were decoronated and 2 mm dentin slices were prepared. Specimens were divided equally into the following groups: normal saline and CHX, Metronidazole, Minocycline, Ciprofloxacin, and combination of Metronidazole, Minocycline and Ciprofloxacin. The specimens were irrigated with solutions and filled with endodontic cements. In the second part, the endodontic cements were mixed, placed in plastic tubes and then irrigated for 1 or 5 min. Push-out and surface microhardness values were calculated and data were analyzed with three way ANOVA followed by Tukey's post-hoc test. Results The normal saline and ciprofloxacin groups showed significantly higher and lower, respectively, push-out bond strength among the experimental groups (p < 0.001 for all groups). Nano type cement showed higher push-out bond strength and microhardness than regular one at both time intervals. The mixture of antibiotics had significant effects on the push out and microhardness of calcium silicate cement. Conclusions Nano particle MTA resisted more than the conventional MTA to the effect of the irrigating solution and antibiotics in both hardness and push-out strength. Furthermore, the results of microhardness were consistent with the push-out strength in most cases. The microhardness test may be employed as a complimentary test to evaluate push-out strength of dental cements.

AB - Aim To evaluate the influence of Metronidazole, Minocycline and Ciprofloxacin as a mixture or individually and of chlorhexidine on the push-out bond strength and surface microhardness of calcium silicate cements of differing particle size. Methodology 120 extracted adult human premolars were decoronated and 2 mm dentin slices were prepared. Specimens were divided equally into the following groups: normal saline and CHX, Metronidazole, Minocycline, Ciprofloxacin, and combination of Metronidazole, Minocycline and Ciprofloxacin. The specimens were irrigated with solutions and filled with endodontic cements. In the second part, the endodontic cements were mixed, placed in plastic tubes and then irrigated for 1 or 5 min. Push-out and surface microhardness values were calculated and data were analyzed with three way ANOVA followed by Tukey's post-hoc test. Results The normal saline and ciprofloxacin groups showed significantly higher and lower, respectively, push-out bond strength among the experimental groups (p < 0.001 for all groups). Nano type cement showed higher push-out bond strength and microhardness than regular one at both time intervals. The mixture of antibiotics had significant effects on the push out and microhardness of calcium silicate cement. Conclusions Nano particle MTA resisted more than the conventional MTA to the effect of the irrigating solution and antibiotics in both hardness and push-out strength. Furthermore, the results of microhardness were consistent with the push-out strength in most cases. The microhardness test may be employed as a complimentary test to evaluate push-out strength of dental cements.

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