The influence of gestational age and preeclampsia on the presence and magnitude of serum endogenous digoxin-like immunoreactive substance(s)

Stephanie Phelps, Emily B. Cochran, Antonio Gonzalez-Ruiz, Elizabeth Tolley, Katherine D. Hammond, Baha M. Sibai

Research output: Contribution to journalArticle

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Abstract

Digoxin-like immunoreactive substance(s) has been measured in serum during pregnancy. Because of its presence in pregnancy, investigators have suggested that digoxin-like immunoreactive substance may play an etiologic role in the development of preeclampsia. The objectives of this study were to evaluate the relationship between maternal digoxin-like immunoreactive substance and gestational age and compare digoxin-like immunoreactive substance concentrations in patients with and without preeclampsia who were in the third trimester. Two hundred twenty patients were studied during either the first (n = 53), second (n = 56), or third (n = 111) trimester of pregnancy. Digoxin-like immunoreactive substance was undetectable in the serum of patients during the first trimester; however, 11% of second-trimester and 96% of third-trimester patients had measurable levels of serum digoxin-like immunoreactive substance (p < 0.05). The mean ± SEM concentration of digoxin-like immunoreactive substance in serum in third-trimester patients was 0.29 ± 0.01 ng/ml (range 0 to 0.58 ng/ml). Gestational age at delivery was significantly lower in patients with preeclampsia than in those without preeclampsia (36.3 ± 0.6 versus 38.8 ± 0.4 weeks; p < 0.001). In addition, there was no statistical difference in mean ± SEM concentration of digoxin-like immunoreactive substance between 27 patients without preeclampsia (0.32 ± 0.02 ng/ml) and 27 patients with preeclampsia (0.30 ± 0.02 ng/ml; p = 0.47) matched for gestational age. We conclude that (1) digoxin-like immunoreactive substance appearance and increasing serum concentration during pregnancy are correlated with increasing gestational age and (2) there is no difference in digoxin-like immunoreactive substance values between patients with and without preeclampsia, which may exclude digoxin-like immunoreactive substance as a predictor of preeclampsia.

Original languageEnglish (US)
Pages (from-to)34-39
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume158
Issue number1
DOIs
StatePublished - 1988

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Pre-Eclampsia
Gestational Age
Serum
Third Pregnancy Trimester
Pregnancy
digoxin-like factors
Pregnancy Trimesters
Second Pregnancy Trimester
First Pregnancy Trimester
Mothers
Research Personnel

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

The influence of gestational age and preeclampsia on the presence and magnitude of serum endogenous digoxin-like immunoreactive substance(s). / Phelps, Stephanie; Cochran, Emily B.; Gonzalez-Ruiz, Antonio; Tolley, Elizabeth; Hammond, Katherine D.; Sibai, Baha M.

In: American Journal of Obstetrics and Gynecology, Vol. 158, No. 1, 1988, p. 34-39.

Research output: Contribution to journalArticle

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abstract = "Digoxin-like immunoreactive substance(s) has been measured in serum during pregnancy. Because of its presence in pregnancy, investigators have suggested that digoxin-like immunoreactive substance may play an etiologic role in the development of preeclampsia. The objectives of this study were to evaluate the relationship between maternal digoxin-like immunoreactive substance and gestational age and compare digoxin-like immunoreactive substance concentrations in patients with and without preeclampsia who were in the third trimester. Two hundred twenty patients were studied during either the first (n = 53), second (n = 56), or third (n = 111) trimester of pregnancy. Digoxin-like immunoreactive substance was undetectable in the serum of patients during the first trimester; however, 11{\%} of second-trimester and 96{\%} of third-trimester patients had measurable levels of serum digoxin-like immunoreactive substance (p < 0.05). The mean ± SEM concentration of digoxin-like immunoreactive substance in serum in third-trimester patients was 0.29 ± 0.01 ng/ml (range 0 to 0.58 ng/ml). Gestational age at delivery was significantly lower in patients with preeclampsia than in those without preeclampsia (36.3 ± 0.6 versus 38.8 ± 0.4 weeks; p < 0.001). In addition, there was no statistical difference in mean ± SEM concentration of digoxin-like immunoreactive substance between 27 patients without preeclampsia (0.32 ± 0.02 ng/ml) and 27 patients with preeclampsia (0.30 ± 0.02 ng/ml; p = 0.47) matched for gestational age. We conclude that (1) digoxin-like immunoreactive substance appearance and increasing serum concentration during pregnancy are correlated with increasing gestational age and (2) there is no difference in digoxin-like immunoreactive substance values between patients with and without preeclampsia, which may exclude digoxin-like immunoreactive substance as a predictor of preeclampsia.",
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