The influence of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine on citrate content, activities of aconitase and citrate synthase in rats exposed to cerebral ischemia-reperfusion

O. V. Sukhoveeva, T. N. Popova, A. V. Makeeva, Igor Iskusnykh

Research output: Contribution to journalArticle

Abstract

The effect of guanidine derivatives on citrate content and activity of aconitate hydratase and citrate synthase have been investigated in rats with cerebral ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl] guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes of specific activities of aconitase and citrate synthase towards control values. Under these conditions the citrate level considerably decreased versus rats with untreated ishemia-reperfusion. Administration of these biguanidines compounds also decreased the degree of DNA fragmentation, which was markedly increased in rats with ischemia-reperfusion. The dose-dependent effects of guanidine derivatives suggest that they exhibit not only antioxidant but also prooxidant effects.

Original languageEnglish (US)
Pages (from-to)171-176
Number of pages6
JournalBiochemistry (Moscow) Supplement Series B: Biomedical Chemistry
Volume6
Issue number2
DOIs
StatePublished - Apr 1 2012

Fingerprint

Methylguanidine
Aconitate Hydratase
Citrate (si)-Synthase
Brain Ischemia
Citric Acid
Reperfusion
Rats
Guanidine
Derivatives
DNA Fragmentation
Ischemia
Antioxidants
DNA
N-(imino(1-piperidinyl)methyl)guanidine

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

Cite this

@article{d028fb8c7020485095efcce9d7c50623,
title = "The influence of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine on citrate content, activities of aconitase and citrate synthase in rats exposed to cerebral ischemia-reperfusion",
abstract = "The effect of guanidine derivatives on citrate content and activity of aconitate hydratase and citrate synthase have been investigated in rats with cerebral ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl] guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes of specific activities of aconitase and citrate synthase towards control values. Under these conditions the citrate level considerably decreased versus rats with untreated ishemia-reperfusion. Administration of these biguanidines compounds also decreased the degree of DNA fragmentation, which was markedly increased in rats with ischemia-reperfusion. The dose-dependent effects of guanidine derivatives suggest that they exhibit not only antioxidant but also prooxidant effects.",
author = "Sukhoveeva, {O. V.} and Popova, {T. N.} and Makeeva, {A. V.} and Igor Iskusnykh",
year = "2012",
month = "4",
day = "1",
doi = "10.1134/S1990750812020138",
language = "English (US)",
volume = "6",
pages = "171--176",
journal = "Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry",
issn = "1990-7508",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "2",

}

TY - JOUR

T1 - The influence of N-[imino(1-piperidinyl)methyl]guanidine and N-[imino(4-morpholinyl)methyl]guanidine on citrate content, activities of aconitase and citrate synthase in rats exposed to cerebral ischemia-reperfusion

AU - Sukhoveeva, O. V.

AU - Popova, T. N.

AU - Makeeva, A. V.

AU - Iskusnykh, Igor

PY - 2012/4/1

Y1 - 2012/4/1

N2 - The effect of guanidine derivatives on citrate content and activity of aconitate hydratase and citrate synthase have been investigated in rats with cerebral ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl] guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes of specific activities of aconitase and citrate synthase towards control values. Under these conditions the citrate level considerably decreased versus rats with untreated ishemia-reperfusion. Administration of these biguanidines compounds also decreased the degree of DNA fragmentation, which was markedly increased in rats with ischemia-reperfusion. The dose-dependent effects of guanidine derivatives suggest that they exhibit not only antioxidant but also prooxidant effects.

AB - The effect of guanidine derivatives on citrate content and activity of aconitate hydratase and citrate synthase have been investigated in rats with cerebral ischemia-reperfusion. Administration of N-[imino(1-piperidinyl)methyl] guanidine and N-[imino(4-morpholinyl)methyl]guanidine resulted in changes of specific activities of aconitase and citrate synthase towards control values. Under these conditions the citrate level considerably decreased versus rats with untreated ishemia-reperfusion. Administration of these biguanidines compounds also decreased the degree of DNA fragmentation, which was markedly increased in rats with ischemia-reperfusion. The dose-dependent effects of guanidine derivatives suggest that they exhibit not only antioxidant but also prooxidant effects.

UR - http://www.scopus.com/inward/record.url?scp=84863697594&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863697594&partnerID=8YFLogxK

U2 - 10.1134/S1990750812020138

DO - 10.1134/S1990750812020138

M3 - Article

AN - SCOPUS:84863697594

VL - 6

SP - 171

EP - 176

JO - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

JF - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry

SN - 1990-7508

IS - 2

ER -