The influence of rapid onsite evaluation on the adequacy rate of fine-needle aspiration cytology

A systematic review and meta-analysis

Robert L. Schmidt, Benjamin L. Witt, Leslie Lopez-Calderon, Lester J. Layfield

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Rapid onsite evaluation (ROSE) has the potential to improve the adequacy rates of fine-needle aspiration (FNA) cytology. Studies have obtained variable results on the influence of ROSE. We conducted a systematic review and meta-analysis of studies on the influence of ROSE on FNA adequacy. We synthesized evidence across all anatomic locations. We only included studies that contained a control arm and compared cohorts with ROSE against cohorts without ROSE at a single location. We screened 2,179 studies and identified 25 studies that met our inclusion criteria. On average, ROSE improves the adequacy rate by 12%, but there was considerable variability across studies. The adequacy rate with ROSE depends on the non-ROSE adequacy rate. Sixty-five percent of the variability in the adequacy rate with ROSE was found to occur because of differences in the adequacy rate without ROSE. Studies with high non-ROSE adequacy rates showed low improvement after ROSE was implemented. Studies must account for the effect of the non-ROSE adequacy rate to determine the effect of ROSE on FNA adequacy rates.

Original languageEnglish (US)
Pages (from-to)300-308
Number of pages9
JournalAmerican Journal of Clinical Pathology
Volume139
Issue number3
DOIs
StatePublished - Mar 1 2013
Externally publishedYes

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Fine Needle Biopsy
Cell Biology
Meta-Analysis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

The influence of rapid onsite evaluation on the adequacy rate of fine-needle aspiration cytology : A systematic review and meta-analysis. / Schmidt, Robert L.; Witt, Benjamin L.; Lopez-Calderon, Leslie; Layfield, Lester J.

In: American Journal of Clinical Pathology, Vol. 139, No. 3, 01.03.2013, p. 300-308.

Research output: Contribution to journalArticle

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