The innate immune response during urinary tract infection and pyelonephritis

John David Spencer, Andrew L. Schwaderer, Brian Becknell, Joshua Watson, David Hains

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

Despite its proximity to the fecal flora, the urinary tract is considered sterile. The precise mechanisms by which the urinary tract maintains sterility are not well understood. Host immune responses are critically important in the antimicrobial defense of the urinary tract. During recent years, considerable advances have been made in our understanding of the mechanisms underlying immune homeostasis of the kidney and urinary tract. Dysfunctions in these immune mechanisms may result in acute disease, tissue destruction and overwhelming infection. The objective of this review is to provide an overview of the innate immune response in the urinary tract in response to microbial assault. In doing so, we focus on the role of antimicrobial peptides - a ubiquitous component of the innate immune response.

Original languageEnglish (US)
Pages (from-to)1139-1149
Number of pages11
JournalPediatric Nephrology
Volume29
Issue number7
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Pyelonephritis
Urinary Tract
Innate Immunity
Urinary Tract Infections
Acute Disease
Infertility
Homeostasis
Kidney
Peptides
Infection

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

The innate immune response during urinary tract infection and pyelonephritis. / Spencer, John David; Schwaderer, Andrew L.; Becknell, Brian; Watson, Joshua; Hains, David.

In: Pediatric Nephrology, Vol. 29, No. 7, 01.01.2014, p. 1139-1149.

Research output: Contribution to journalReview article

Spencer, John David ; Schwaderer, Andrew L. ; Becknell, Brian ; Watson, Joshua ; Hains, David. / The innate immune response during urinary tract infection and pyelonephritis. In: Pediatric Nephrology. 2014 ; Vol. 29, No. 7. pp. 1139-1149.
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