The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia

John R. Srigley, Brett Delahunt, John N. Eble, Lars Egevad, Jonathan I. Epstein, David Grignon, Ondrej Hes, Holger Moch, Rodolfo Montironi, Satish K. Tickoo, Ming Zhou, Pedram Argani, Anila Abraham, Adebowale Adeniran, Khalid Ahmed, Hikmat Al Ahmadie, Ferran Algaba, Robert Allan, Mahul Amin, Ulrika Axcrona & 115 others Marc Barry, Dilek Baydar, Louis Bégin, Dan Berney, Peter Bethwaite, Athanase Billis, Ruth Birbe, Stephen Bonsib, David Bostwick, Fadi Brimo, Helen Cathro, Ying Bei Chen, Liang Cheng, John Cheville, Yong Mee Cho, Ai Ying Chuang, Cynthia Cohen, Henry Crist, Warick Delprado, Fang Ming Deng, Andrew Evans, Oluwole Fadare, Daniel Fajardo, Sara Falzarano, Samson Fine, Stewart Fleming, Eddie Fridman, Bungo Furusato, Masoud Ganji, Masoumeh Ghayouri, Giovanna Giannico, Neriman Gokden, David Griffiths, Nilesh Gupta, Omar Hameed, Michelle Hirsch, Jiaoti Huang, Wei Huang, Christina Hulsbergen Van De Kaa, Peter Humphrey, Sundus Hussein, Kenneth Iczkowski, Rafael Jimenez, Edward Jones, Laura Irene Jufe, James Kench, Masatoshi Kida, Glen Kristiansen, Lakshmi Priya Kunju, Zhaoli Lane, Mathieu Latour, Claudio Lewin, Kathrine Lie, Josep Lloreta, Barbara Loftus, Antonio Lopez-Beltran, Fiona Maclean, Cristina Magi-Galluzzi, Guido Martignoni, Teresa McHale, Jesse McKenney, Maria Merino, Rose Miller, Hiroshi Miyamoto, Hedwig Murphy, John Nacey, Tipu Nazeer, Gabriella Nesi, George Netto, Peter Nichols, Marie O'Donnell, Semra Olgac, Roberto Orozco, Adeboye Osunkoya, Aysim Ozagari, Chin Chen Pan, Anil Parwani, Joanna Perry-Keene, Constantina Petraki, Maria Picken, Maria Pyda-Karwicka, Victor Reuter, Katayoon Rezaei, Nathalie Rioux-Leclercq, Brian Robinson, Stephen Rohan, Ruben Ronchetti, Laurie Russell, Hemamali Samaratunga, Marina Scarpelli, Ahmed Shabaik, Rajal Shah, Jonathan Shanks, Steven Shen, Maria Shevchuk, Mathilde Sibony, Bhuvana Srinivasan, Martin Susani, Sueli Suzigan, Joan Sweet, Hiroyuki Takahashi, Pheroze Tamboli, Puay Hoon Tan, Isabel Trias, Kiril Trpkov, Larry True, Toyonori Tsuzuki, Funda Vakar-Lopez, Theo Van Der Kwast, Cheng Wang, Anne Warren, Jorge Yao, Asli Yilmaz, Jin Zhao, Debra Zynger

Research output: Contribution to journalArticle

545 Citations (Scopus)

Abstract

The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group performed an exhaustive literature review, assessed the results of the preconference survey and participated in the consensus conference discussion and polling activities. On the basis of the above inputs, there was consensus that 5 entities should be recognized as new distinct epithelial tumors within the classification system: tubulocystic renal cell carcinoma (RCC), acquired cystic disease-associated RCC, clear cell (tubulo) papillary RCC, the MiT family translocation RCCs (in particular t(6;11) RCC), and hereditary leiomyomatosis RCC syndrome-associated RCC. In addition, there are 3 rare carcinomas that were considered as emerging or provisional new entities: thyroid-like follicular RCC; succinate dehydrogenase B deficiency-associated RCC; and ALK translocation RCC. Further reports of these entities are required to better understand the nature and behavior of these highly unusual tumors. There were a number of new concepts and suggested modifications to the existing World Health Organization 2004 categories. Within the clear cell RCC group, it was agreed upon that multicystic clear cell RCC is best considered as a neoplasm of low malignant potential. There was agreement that subtyping of papillary RCC is of value and that the oncocytic variant of papillary RCC should not be considered as a distinct entity. The hybrid oncocytic chromophobe tumor, which is an indolent tumor that occurs in 3 settings, namely Birt-Hogg-Dubé Syndrome, renal oncocytosis, and as a sporadic neoplasm, was placed, for the time being, within the chromophobe RCC category. Recent advances related to collecting duct carcinoma, renal medullary carcinoma, and mucinous spindle cell and tubular RCC were elucidated. Outside of the epithelial category, advances in our understanding of angiomyolipoma, including the epithelioid and epithelial cystic variants, were considered. In addition, the apparent relationship between cystic nephroma and mixed epithelial and stromal tumor was discussed, with the consensus that these tumors form a spectrum of neoplasia. Finally, it was thought that the synovial sarcoma should be removed from the mixed epithelial and mesenchymal category and placed within the sarcoma group. The new classification is to be referred to as the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia.

Original languageEnglish (US)
Pages (from-to)1469-1489
Number of pages21
JournalAmerican Journal of Surgical Pathology
Volume37
Issue number10
DOIs
StatePublished - Jan 1 2013

Fingerprint

Renal Cell Carcinoma
Pathology
Kidney
Neoplasms
Leiomyomatosis
Synovial Sarcoma
Angiomyolipoma
Medullary Carcinoma
Succinate Dehydrogenase
Sarcoma
Thyroid Gland
Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

Cite this

Srigley, J. R., Delahunt, B., Eble, J. N., Egevad, L., Epstein, J. I., Grignon, D., ... Zynger, D. (2013). The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia. American Journal of Surgical Pathology, 37(10), 1469-1489. https://doi.org/10.1097/PAS.0b013e318299f2d1

The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia. / Srigley, John R.; Delahunt, Brett; Eble, John N.; Egevad, Lars; Epstein, Jonathan I.; Grignon, David; Hes, Ondrej; Moch, Holger; Montironi, Rodolfo; Tickoo, Satish K.; Zhou, Ming; Argani, Pedram; Abraham, Anila; Adeniran, Adebowale; Ahmed, Khalid; Al Ahmadie, Hikmat; Algaba, Ferran; Allan, Robert; Amin, Mahul; Axcrona, Ulrika; Barry, Marc; Baydar, Dilek; Bégin, Louis; Berney, Dan; Bethwaite, Peter; Billis, Athanase; Birbe, Ruth; Bonsib, Stephen; Bostwick, David; Brimo, Fadi; Cathro, Helen; Chen, Ying Bei; Cheng, Liang; Cheville, John; Cho, Yong Mee; Chuang, Ai Ying; Cohen, Cynthia; Crist, Henry; Delprado, Warick; Deng, Fang Ming; Evans, Andrew; Fadare, Oluwole; Fajardo, Daniel; Falzarano, Sara; Fine, Samson; Fleming, Stewart; Fridman, Eddie; Furusato, Bungo; Ganji, Masoud; Ghayouri, Masoumeh; Giannico, Giovanna; Gokden, Neriman; Griffiths, David; Gupta, Nilesh; Hameed, Omar; Hirsch, Michelle; Huang, Jiaoti; Huang, Wei; Van De Kaa, Christina Hulsbergen; Humphrey, Peter; Hussein, Sundus; Iczkowski, Kenneth; Jimenez, Rafael; Jones, Edward; Jufe, Laura Irene; Kench, James; Kida, Masatoshi; Kristiansen, Glen; Kunju, Lakshmi Priya; Lane, Zhaoli; Latour, Mathieu; Lewin, Claudio; Lie, Kathrine; Lloreta, Josep; Loftus, Barbara; Lopez-Beltran, Antonio; Maclean, Fiona; Magi-Galluzzi, Cristina; Martignoni, Guido; McHale, Teresa; McKenney, Jesse; Merino, Maria; Miller, Rose; Miyamoto, Hiroshi; Murphy, Hedwig; Nacey, John; Nazeer, Tipu; Nesi, Gabriella; Netto, George; Nichols, Peter; O'Donnell, Marie; Olgac, Semra; Orozco, Roberto; Osunkoya, Adeboye; Ozagari, Aysim; Pan, Chin Chen; Parwani, Anil; Perry-Keene, Joanna; Petraki, Constantina; Picken, Maria; Pyda-Karwicka, Maria; Reuter, Victor; Rezaei, Katayoon; Rioux-Leclercq, Nathalie; Robinson, Brian; Rohan, Stephen; Ronchetti, Ruben; Russell, Laurie; Samaratunga, Hemamali; Scarpelli, Marina; Shabaik, Ahmed; Shah, Rajal; Shanks, Jonathan; Shen, Steven; Shevchuk, Maria; Sibony, Mathilde; Srinivasan, Bhuvana; Susani, Martin; Suzigan, Sueli; Sweet, Joan; Takahashi, Hiroyuki; Tamboli, Pheroze; Tan, Puay Hoon; Trias, Isabel; Trpkov, Kiril; True, Larry; Tsuzuki, Toyonori; Vakar-Lopez, Funda; Van Der Kwast, Theo; Wang, Cheng; Warren, Anne; Yao, Jorge; Yilmaz, Asli; Zhao, Jin; Zynger, Debra.

In: American Journal of Surgical Pathology, Vol. 37, No. 10, 01.01.2013, p. 1469-1489.

Research output: Contribution to journalArticle

Srigley, JR, Delahunt, B, Eble, JN, Egevad, L, Epstein, JI, Grignon, D, Hes, O, Moch, H, Montironi, R, Tickoo, SK, Zhou, M, Argani, P, Abraham, A, Adeniran, A, Ahmed, K, Al Ahmadie, H, Algaba, F, Allan, R, Amin, M, Axcrona, U, Barry, M, Baydar, D, Bégin, L, Berney, D, Bethwaite, P, Billis, A, Birbe, R, Bonsib, S, Bostwick, D, Brimo, F, Cathro, H, Chen, YB, Cheng, L, Cheville, J, Cho, YM, Chuang, AY, Cohen, C, Crist, H, Delprado, W, Deng, FM, Evans, A, Fadare, O, Fajardo, D, Falzarano, S, Fine, S, Fleming, S, Fridman, E, Furusato, B, Ganji, M, Ghayouri, M, Giannico, G, Gokden, N, Griffiths, D, Gupta, N, Hameed, O, Hirsch, M, Huang, J, Huang, W, Van De Kaa, CH, Humphrey, P, Hussein, S, Iczkowski, K, Jimenez, R, Jones, E, Jufe, LI, Kench, J, Kida, M, Kristiansen, G, Kunju, LP, Lane, Z, Latour, M, Lewin, C, Lie, K, Lloreta, J, Loftus, B, Lopez-Beltran, A, Maclean, F, Magi-Galluzzi, C, Martignoni, G, McHale, T, McKenney, J, Merino, M, Miller, R, Miyamoto, H, Murphy, H, Nacey, J, Nazeer, T, Nesi, G, Netto, G, Nichols, P, O'Donnell, M, Olgac, S, Orozco, R, Osunkoya, A, Ozagari, A, Pan, CC, Parwani, A, Perry-Keene, J, Petraki, C, Picken, M, Pyda-Karwicka, M, Reuter, V, Rezaei, K, Rioux-Leclercq, N, Robinson, B, Rohan, S, Ronchetti, R, Russell, L, Samaratunga, H, Scarpelli, M, Shabaik, A, Shah, R, Shanks, J, Shen, S, Shevchuk, M, Sibony, M, Srinivasan, B, Susani, M, Suzigan, S, Sweet, J, Takahashi, H, Tamboli, P, Tan, PH, Trias, I, Trpkov, K, True, L, Tsuzuki, T, Vakar-Lopez, F, Van Der Kwast, T, Wang, C, Warren, A, Yao, J, Yilmaz, A, Zhao, J & Zynger, D 2013, 'The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia', American Journal of Surgical Pathology, vol. 37, no. 10, pp. 1469-1489. https://doi.org/10.1097/PAS.0b013e318299f2d1
Srigley, John R. ; Delahunt, Brett ; Eble, John N. ; Egevad, Lars ; Epstein, Jonathan I. ; Grignon, David ; Hes, Ondrej ; Moch, Holger ; Montironi, Rodolfo ; Tickoo, Satish K. ; Zhou, Ming ; Argani, Pedram ; Abraham, Anila ; Adeniran, Adebowale ; Ahmed, Khalid ; Al Ahmadie, Hikmat ; Algaba, Ferran ; Allan, Robert ; Amin, Mahul ; Axcrona, Ulrika ; Barry, Marc ; Baydar, Dilek ; Bégin, Louis ; Berney, Dan ; Bethwaite, Peter ; Billis, Athanase ; Birbe, Ruth ; Bonsib, Stephen ; Bostwick, David ; Brimo, Fadi ; Cathro, Helen ; Chen, Ying Bei ; Cheng, Liang ; Cheville, John ; Cho, Yong Mee ; Chuang, Ai Ying ; Cohen, Cynthia ; Crist, Henry ; Delprado, Warick ; Deng, Fang Ming ; Evans, Andrew ; Fadare, Oluwole ; Fajardo, Daniel ; Falzarano, Sara ; Fine, Samson ; Fleming, Stewart ; Fridman, Eddie ; Furusato, Bungo ; Ganji, Masoud ; Ghayouri, Masoumeh ; Giannico, Giovanna ; Gokden, Neriman ; Griffiths, David ; Gupta, Nilesh ; Hameed, Omar ; Hirsch, Michelle ; Huang, Jiaoti ; Huang, Wei ; Van De Kaa, Christina Hulsbergen ; Humphrey, Peter ; Hussein, Sundus ; Iczkowski, Kenneth ; Jimenez, Rafael ; Jones, Edward ; Jufe, Laura Irene ; Kench, James ; Kida, Masatoshi ; Kristiansen, Glen ; Kunju, Lakshmi Priya ; Lane, Zhaoli ; Latour, Mathieu ; Lewin, Claudio ; Lie, Kathrine ; Lloreta, Josep ; Loftus, Barbara ; Lopez-Beltran, Antonio ; Maclean, Fiona ; Magi-Galluzzi, Cristina ; Martignoni, Guido ; McHale, Teresa ; McKenney, Jesse ; Merino, Maria ; Miller, Rose ; Miyamoto, Hiroshi ; Murphy, Hedwig ; Nacey, John ; Nazeer, Tipu ; Nesi, Gabriella ; Netto, George ; Nichols, Peter ; O'Donnell, Marie ; Olgac, Semra ; Orozco, Roberto ; Osunkoya, Adeboye ; Ozagari, Aysim ; Pan, Chin Chen ; Parwani, Anil ; Perry-Keene, Joanna ; Petraki, Constantina ; Picken, Maria ; Pyda-Karwicka, Maria ; Reuter, Victor ; Rezaei, Katayoon ; Rioux-Leclercq, Nathalie ; Robinson, Brian ; Rohan, Stephen ; Ronchetti, Ruben ; Russell, Laurie ; Samaratunga, Hemamali ; Scarpelli, Marina ; Shabaik, Ahmed ; Shah, Rajal ; Shanks, Jonathan ; Shen, Steven ; Shevchuk, Maria ; Sibony, Mathilde ; Srinivasan, Bhuvana ; Susani, Martin ; Suzigan, Sueli ; Sweet, Joan ; Takahashi, Hiroyuki ; Tamboli, Pheroze ; Tan, Puay Hoon ; Trias, Isabel ; Trpkov, Kiril ; True, Larry ; Tsuzuki, Toyonori ; Vakar-Lopez, Funda ; Van Der Kwast, Theo ; Wang, Cheng ; Warren, Anne ; Yao, Jorge ; Yilmaz, Asli ; Zhao, Jin ; Zynger, Debra. / The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia. In: American Journal of Surgical Pathology. 2013 ; Vol. 37, No. 10. pp. 1469-1489.
@article{c22ba0c04cb84369b66fdef1057e4bb6,
title = "The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia",
abstract = "The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group performed an exhaustive literature review, assessed the results of the preconference survey and participated in the consensus conference discussion and polling activities. On the basis of the above inputs, there was consensus that 5 entities should be recognized as new distinct epithelial tumors within the classification system: tubulocystic renal cell carcinoma (RCC), acquired cystic disease-associated RCC, clear cell (tubulo) papillary RCC, the MiT family translocation RCCs (in particular t(6;11) RCC), and hereditary leiomyomatosis RCC syndrome-associated RCC. In addition, there are 3 rare carcinomas that were considered as emerging or provisional new entities: thyroid-like follicular RCC; succinate dehydrogenase B deficiency-associated RCC; and ALK translocation RCC. Further reports of these entities are required to better understand the nature and behavior of these highly unusual tumors. There were a number of new concepts and suggested modifications to the existing World Health Organization 2004 categories. Within the clear cell RCC group, it was agreed upon that multicystic clear cell RCC is best considered as a neoplasm of low malignant potential. There was agreement that subtyping of papillary RCC is of value and that the oncocytic variant of papillary RCC should not be considered as a distinct entity. The hybrid oncocytic chromophobe tumor, which is an indolent tumor that occurs in 3 settings, namely Birt-Hogg-Dub{\'e} Syndrome, renal oncocytosis, and as a sporadic neoplasm, was placed, for the time being, within the chromophobe RCC category. Recent advances related to collecting duct carcinoma, renal medullary carcinoma, and mucinous spindle cell and tubular RCC were elucidated. Outside of the epithelial category, advances in our understanding of angiomyolipoma, including the epithelioid and epithelial cystic variants, were considered. In addition, the apparent relationship between cystic nephroma and mixed epithelial and stromal tumor was discussed, with the consensus that these tumors form a spectrum of neoplasia. Finally, it was thought that the synovial sarcoma should be removed from the mixed epithelial and mesenchymal category and placed within the sarcoma group. The new classification is to be referred to as the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia.",
author = "Srigley, {John R.} and Brett Delahunt and Eble, {John N.} and Lars Egevad and Epstein, {Jonathan I.} and David Grignon and Ondrej Hes and Holger Moch and Rodolfo Montironi and Tickoo, {Satish K.} and Ming Zhou and Pedram Argani and Anila Abraham and Adebowale Adeniran and Khalid Ahmed and {Al Ahmadie}, Hikmat and Ferran Algaba and Robert Allan and Mahul Amin and Ulrika Axcrona and Marc Barry and Dilek Baydar and Louis B{\'e}gin and Dan Berney and Peter Bethwaite and Athanase Billis and Ruth Birbe and Stephen Bonsib and David Bostwick and Fadi Brimo and Helen Cathro and Chen, {Ying Bei} and Liang Cheng and John Cheville and Cho, {Yong Mee} and Chuang, {Ai Ying} and Cynthia Cohen and Henry Crist and Warick Delprado and Deng, {Fang Ming} and Andrew Evans and Oluwole Fadare and Daniel Fajardo and Sara Falzarano and Samson Fine and Stewart Fleming and Eddie Fridman and Bungo Furusato and Masoud Ganji and Masoumeh Ghayouri and Giovanna Giannico and Neriman Gokden and David Griffiths and Nilesh Gupta and Omar Hameed and Michelle Hirsch and Jiaoti Huang and Wei Huang and {Van De Kaa}, {Christina Hulsbergen} and Peter Humphrey and Sundus Hussein and Kenneth Iczkowski and Rafael Jimenez and Edward Jones and Jufe, {Laura Irene} and James Kench and Masatoshi Kida and Glen Kristiansen and Kunju, {Lakshmi Priya} and Zhaoli Lane and Mathieu Latour and Claudio Lewin and Kathrine Lie and Josep Lloreta and Barbara Loftus and Antonio Lopez-Beltran and Fiona Maclean and Cristina Magi-Galluzzi and Guido Martignoni and Teresa McHale and Jesse McKenney and Maria Merino and Rose Miller and Hiroshi Miyamoto and Hedwig Murphy and John Nacey and Tipu Nazeer and Gabriella Nesi and George Netto and Peter Nichols and Marie O'Donnell and Semra Olgac and Roberto Orozco and Adeboye Osunkoya and Aysim Ozagari and Pan, {Chin Chen} and Anil Parwani and Joanna Perry-Keene and Constantina Petraki and Maria Picken and Maria Pyda-Karwicka and Victor Reuter and Katayoon Rezaei and Nathalie Rioux-Leclercq and Brian Robinson and Stephen Rohan and Ruben Ronchetti and Laurie Russell and Hemamali Samaratunga and Marina Scarpelli and Ahmed Shabaik and Rajal Shah and Jonathan Shanks and Steven Shen and Maria Shevchuk and Mathilde Sibony and Bhuvana Srinivasan and Martin Susani and Sueli Suzigan and Joan Sweet and Hiroyuki Takahashi and Pheroze Tamboli and Tan, {Puay Hoon} and Isabel Trias and Kiril Trpkov and Larry True and Toyonori Tsuzuki and Funda Vakar-Lopez and {Van Der Kwast}, Theo and Cheng Wang and Anne Warren and Jorge Yao and Asli Yilmaz and Jin Zhao and Debra Zynger",
year = "2013",
month = "1",
day = "1",
doi = "10.1097/PAS.0b013e318299f2d1",
language = "English (US)",
volume = "37",
pages = "1469--1489",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia

AU - Srigley, John R.

AU - Delahunt, Brett

AU - Eble, John N.

AU - Egevad, Lars

AU - Epstein, Jonathan I.

AU - Grignon, David

AU - Hes, Ondrej

AU - Moch, Holger

AU - Montironi, Rodolfo

AU - Tickoo, Satish K.

AU - Zhou, Ming

AU - Argani, Pedram

AU - Abraham, Anila

AU - Adeniran, Adebowale

AU - Ahmed, Khalid

AU - Al Ahmadie, Hikmat

AU - Algaba, Ferran

AU - Allan, Robert

AU - Amin, Mahul

AU - Axcrona, Ulrika

AU - Barry, Marc

AU - Baydar, Dilek

AU - Bégin, Louis

AU - Berney, Dan

AU - Bethwaite, Peter

AU - Billis, Athanase

AU - Birbe, Ruth

AU - Bonsib, Stephen

AU - Bostwick, David

AU - Brimo, Fadi

AU - Cathro, Helen

AU - Chen, Ying Bei

AU - Cheng, Liang

AU - Cheville, John

AU - Cho, Yong Mee

AU - Chuang, Ai Ying

AU - Cohen, Cynthia

AU - Crist, Henry

AU - Delprado, Warick

AU - Deng, Fang Ming

AU - Evans, Andrew

AU - Fadare, Oluwole

AU - Fajardo, Daniel

AU - Falzarano, Sara

AU - Fine, Samson

AU - Fleming, Stewart

AU - Fridman, Eddie

AU - Furusato, Bungo

AU - Ganji, Masoud

AU - Ghayouri, Masoumeh

AU - Giannico, Giovanna

AU - Gokden, Neriman

AU - Griffiths, David

AU - Gupta, Nilesh

AU - Hameed, Omar

AU - Hirsch, Michelle

AU - Huang, Jiaoti

AU - Huang, Wei

AU - Van De Kaa, Christina Hulsbergen

AU - Humphrey, Peter

AU - Hussein, Sundus

AU - Iczkowski, Kenneth

AU - Jimenez, Rafael

AU - Jones, Edward

AU - Jufe, Laura Irene

AU - Kench, James

AU - Kida, Masatoshi

AU - Kristiansen, Glen

AU - Kunju, Lakshmi Priya

AU - Lane, Zhaoli

AU - Latour, Mathieu

AU - Lewin, Claudio

AU - Lie, Kathrine

AU - Lloreta, Josep

AU - Loftus, Barbara

AU - Lopez-Beltran, Antonio

AU - Maclean, Fiona

AU - Magi-Galluzzi, Cristina

AU - Martignoni, Guido

AU - McHale, Teresa

AU - McKenney, Jesse

AU - Merino, Maria

AU - Miller, Rose

AU - Miyamoto, Hiroshi

AU - Murphy, Hedwig

AU - Nacey, John

AU - Nazeer, Tipu

AU - Nesi, Gabriella

AU - Netto, George

AU - Nichols, Peter

AU - O'Donnell, Marie

AU - Olgac, Semra

AU - Orozco, Roberto

AU - Osunkoya, Adeboye

AU - Ozagari, Aysim

AU - Pan, Chin Chen

AU - Parwani, Anil

AU - Perry-Keene, Joanna

AU - Petraki, Constantina

AU - Picken, Maria

AU - Pyda-Karwicka, Maria

AU - Reuter, Victor

AU - Rezaei, Katayoon

AU - Rioux-Leclercq, Nathalie

AU - Robinson, Brian

AU - Rohan, Stephen

AU - Ronchetti, Ruben

AU - Russell, Laurie

AU - Samaratunga, Hemamali

AU - Scarpelli, Marina

AU - Shabaik, Ahmed

AU - Shah, Rajal

AU - Shanks, Jonathan

AU - Shen, Steven

AU - Shevchuk, Maria

AU - Sibony, Mathilde

AU - Srinivasan, Bhuvana

AU - Susani, Martin

AU - Suzigan, Sueli

AU - Sweet, Joan

AU - Takahashi, Hiroyuki

AU - Tamboli, Pheroze

AU - Tan, Puay Hoon

AU - Trias, Isabel

AU - Trpkov, Kiril

AU - True, Larry

AU - Tsuzuki, Toyonori

AU - Vakar-Lopez, Funda

AU - Van Der Kwast, Theo

AU - Wang, Cheng

AU - Warren, Anne

AU - Yao, Jorge

AU - Yilmaz, Asli

AU - Zhao, Jin

AU - Zynger, Debra

PY - 2013/1/1

Y1 - 2013/1/1

N2 - The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group performed an exhaustive literature review, assessed the results of the preconference survey and participated in the consensus conference discussion and polling activities. On the basis of the above inputs, there was consensus that 5 entities should be recognized as new distinct epithelial tumors within the classification system: tubulocystic renal cell carcinoma (RCC), acquired cystic disease-associated RCC, clear cell (tubulo) papillary RCC, the MiT family translocation RCCs (in particular t(6;11) RCC), and hereditary leiomyomatosis RCC syndrome-associated RCC. In addition, there are 3 rare carcinomas that were considered as emerging or provisional new entities: thyroid-like follicular RCC; succinate dehydrogenase B deficiency-associated RCC; and ALK translocation RCC. Further reports of these entities are required to better understand the nature and behavior of these highly unusual tumors. There were a number of new concepts and suggested modifications to the existing World Health Organization 2004 categories. Within the clear cell RCC group, it was agreed upon that multicystic clear cell RCC is best considered as a neoplasm of low malignant potential. There was agreement that subtyping of papillary RCC is of value and that the oncocytic variant of papillary RCC should not be considered as a distinct entity. The hybrid oncocytic chromophobe tumor, which is an indolent tumor that occurs in 3 settings, namely Birt-Hogg-Dubé Syndrome, renal oncocytosis, and as a sporadic neoplasm, was placed, for the time being, within the chromophobe RCC category. Recent advances related to collecting duct carcinoma, renal medullary carcinoma, and mucinous spindle cell and tubular RCC were elucidated. Outside of the epithelial category, advances in our understanding of angiomyolipoma, including the epithelioid and epithelial cystic variants, were considered. In addition, the apparent relationship between cystic nephroma and mixed epithelial and stromal tumor was discussed, with the consensus that these tumors form a spectrum of neoplasia. Finally, it was thought that the synovial sarcoma should be removed from the mixed epithelial and mesenchymal category and placed within the sarcoma group. The new classification is to be referred to as the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia.

AB - The classification working group of the International Society of Urological Pathology consensus conference on renal neoplasia was in charge of making recommendations regarding additions and changes to the current World Health Organization Classification of Renal Tumors (2004). Members of the group performed an exhaustive literature review, assessed the results of the preconference survey and participated in the consensus conference discussion and polling activities. On the basis of the above inputs, there was consensus that 5 entities should be recognized as new distinct epithelial tumors within the classification system: tubulocystic renal cell carcinoma (RCC), acquired cystic disease-associated RCC, clear cell (tubulo) papillary RCC, the MiT family translocation RCCs (in particular t(6;11) RCC), and hereditary leiomyomatosis RCC syndrome-associated RCC. In addition, there are 3 rare carcinomas that were considered as emerging or provisional new entities: thyroid-like follicular RCC; succinate dehydrogenase B deficiency-associated RCC; and ALK translocation RCC. Further reports of these entities are required to better understand the nature and behavior of these highly unusual tumors. There were a number of new concepts and suggested modifications to the existing World Health Organization 2004 categories. Within the clear cell RCC group, it was agreed upon that multicystic clear cell RCC is best considered as a neoplasm of low malignant potential. There was agreement that subtyping of papillary RCC is of value and that the oncocytic variant of papillary RCC should not be considered as a distinct entity. The hybrid oncocytic chromophobe tumor, which is an indolent tumor that occurs in 3 settings, namely Birt-Hogg-Dubé Syndrome, renal oncocytosis, and as a sporadic neoplasm, was placed, for the time being, within the chromophobe RCC category. Recent advances related to collecting duct carcinoma, renal medullary carcinoma, and mucinous spindle cell and tubular RCC were elucidated. Outside of the epithelial category, advances in our understanding of angiomyolipoma, including the epithelioid and epithelial cystic variants, were considered. In addition, the apparent relationship between cystic nephroma and mixed epithelial and stromal tumor was discussed, with the consensus that these tumors form a spectrum of neoplasia. Finally, it was thought that the synovial sarcoma should be removed from the mixed epithelial and mesenchymal category and placed within the sarcoma group. The new classification is to be referred to as the International Society of Urological Pathology Vancouver Classification of Renal Neoplasia.

UR - http://www.scopus.com/inward/record.url?scp=84900390656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84900390656&partnerID=8YFLogxK

U2 - 10.1097/PAS.0b013e318299f2d1

DO - 10.1097/PAS.0b013e318299f2d1

M3 - Article

VL - 37

SP - 1469

EP - 1489

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 10

ER -