The isomers of cocaine and tropacocaine

Effect on 3H-catecholamine uptake by rat brain synaptosomes

Harold L. Komiskey, Duane Miller, Jules B. LaPidus, Popat N. Patil

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Compared to (+)-pseudococaine, (-)-cocaine was 20 times more potent in inhibiting uptake of 3H-norepinephrine (3HNE) by cortical synaptosomes and 66 times more potent with respect to 3H-dopamine (3HDA) uptake by striatal synaptosomes. Although the tropacocaine isomers were equipotent as inhibitors of 3HNE uptake in the cortex, tropacocaine was 3.9 times more potent as an inhibitor of 3HDa uptake in the striatum than pseudotropococaine. A major known cocaine metabolite, benzoylecgonine failed to inhibit the accumulation of 3HNE and 3HDA by synaptosomes from the cortex and striatum, respectively. The implications of these findings in relation to the motor stimulation seen with (-)-cocaine, (+)-pseudococaine and benzoylecgonine in rats are discussed.

Original languageEnglish (US)
Pages (from-to)1117-1122
Number of pages6
JournalLife Sciences
Volume21
Issue number8
DOIs
StatePublished - Oct 15 1977
Externally publishedYes

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Synaptosomes
Cocaine
Isomers
Catecholamines
Rats
Brain
Norepinephrine
Dopamine
Corpus Striatum
Metabolites
tropacocaine
benzoylecgonine
pseudococaine

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The isomers of cocaine and tropacocaine : Effect on 3H-catecholamine uptake by rat brain synaptosomes. / Komiskey, Harold L.; Miller, Duane; LaPidus, Jules B.; Patil, Popat N.

In: Life Sciences, Vol. 21, No. 8, 15.10.1977, p. 1117-1122.

Research output: Contribution to journalArticle

Komiskey, Harold L. ; Miller, Duane ; LaPidus, Jules B. ; Patil, Popat N. / The isomers of cocaine and tropacocaine : Effect on 3H-catecholamine uptake by rat brain synaptosomes. In: Life Sciences. 1977 ; Vol. 21, No. 8. pp. 1117-1122.
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