The ketogenic diet

Adolescents can do it, too

Mackenzie A. Mady, Eric H. Kossoff, Amy L. McGregor, James Wheless, Paula L. Pyzik, John M. Freeman

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Purpose: To determine both the efficacy of and compliance with the ketogenic diet in the adolescent population. Methods: A retrospective study of 45 patients, aged 12-19 years, consecutively enrolled in a ketogenic diet program from 1994 to 2002, was performed. Thirty-seven patients were from The Johns Hopkins Medical Institutions; eight were from The University of Texas at Houston. Charts were reviewed, and patients were contacted by telephone. Results: Six months after diet initiation, 28 (62%) of 45 remained on the ketogenic diet, with six (21%) of 28 having 50-90% seizure reduction, and eight (29%) of 28 having >90%. At 12 months, 20 (44%) of 45 remained on the diet, with seven (35%) of 20 having 50-90% seizure reduction and six (30%) of 20 achieving >90% efficacy. Only 22% discontinued the diet for perceived restrictiveness. The mean diet duration was 1.2 years. Patients with multiple seizure types did best, whereas gender, prior seizure frequency, diet ratio, and age did not influence outcome. Patients dependent on parents for daily care were more likely to remain on the diet at 6 months, but had less efficacy. Weight loss (60%) and menstrual dysfunction (45% of female subjects) were the most commonly reported side effects. Conclusions: The ketogenic diet is as well tolerated and efficacious for adolescents with epilepsy as for the general childhood population.

Original languageEnglish (US)
Pages (from-to)847-851
Number of pages5
JournalEpilepsia
Volume44
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

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Ketogenic Diet
Diet
Seizures
Telephone
Population
Weight Loss
Epilepsy
Retrospective Studies
Parents

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Mady, M. A., Kossoff, E. H., McGregor, A. L., Wheless, J., Pyzik, P. L., & Freeman, J. M. (2003). The ketogenic diet: Adolescents can do it, too. Epilepsia, 44(6), 847-851. https://doi.org/10.1046/j.1528-1157.2003.57002.x

The ketogenic diet : Adolescents can do it, too. / Mady, Mackenzie A.; Kossoff, Eric H.; McGregor, Amy L.; Wheless, James; Pyzik, Paula L.; Freeman, John M.

In: Epilepsia, Vol. 44, No. 6, 01.06.2003, p. 847-851.

Research output: Contribution to journalArticle

Mady, MA, Kossoff, EH, McGregor, AL, Wheless, J, Pyzik, PL & Freeman, JM 2003, 'The ketogenic diet: Adolescents can do it, too', Epilepsia, vol. 44, no. 6, pp. 847-851. https://doi.org/10.1046/j.1528-1157.2003.57002.x
Mady MA, Kossoff EH, McGregor AL, Wheless J, Pyzik PL, Freeman JM. The ketogenic diet: Adolescents can do it, too. Epilepsia. 2003 Jun 1;44(6):847-851. https://doi.org/10.1046/j.1528-1157.2003.57002.x
Mady, Mackenzie A. ; Kossoff, Eric H. ; McGregor, Amy L. ; Wheless, James ; Pyzik, Paula L. ; Freeman, John M. / The ketogenic diet : Adolescents can do it, too. In: Epilepsia. 2003 ; Vol. 44, No. 6. pp. 847-851.
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