The Kv7 potassium channel activator retigabine decreases alcohol consumption in rats

Clifford M. Knapp, Matthew O'Malley, Subimal Datta, Domenic A. Ciraulo

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Activation of Kv7 potassium channels may decrease the reactivity of mesolimbic dopaminergic neurons that are implicated in mediating the reinforcing effects of ethanol. Objectives: The objective of this study was to determine whether the administration of the Kv7 potassium channel opener retigabine would decrease ethanol intake in Long Evans rats. Methods: A limited access two-bottle choice model of alcohol (10% solution) consumption was used in this study. A separate group of animals was tested to evaluate the actions of retigabine on sucrose (5% solution) consumption to determine whether this drug might produce non-selective impairment of the ability of rats to drink liquids. Animals were treated with either vehicle or increasing doses (2.5-7.5mg/kg SC) of retigabine administered over a 3-day period. Results: Compared to vehicle, retigabine at a dose of 7.5mg/kg produced a reduction in the amount of ethanol consumed. These effects did not occur in association with significant changes in water consumption. A significant time effect was found for the actions of retigabine in sucrose-drinking rats with a trend for an increase in sucrose intake with the highest dose of retigabine administered. Conclusions: These results indicate that the administration of retigabine may produce a decrease in ethanol consumption by rats at doses that do not significantly reduce the drinking of either water or a sucrose solution. These findings are consistent with the hypothesis that activation of Kv7 channels facilitates the reduction of alcohol consumption in the rat.

Original languageEnglish (US)
Pages (from-to)244-250
Number of pages7
JournalAmerican Journal of Drug and Alcohol Abuse
Volume40
Issue number3
DOIs
StatePublished - Jan 1 2014

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Potassium Channels
Alcohol Drinking
Sucrose
Ethanol
Drinking
Long Evans Rats
Aptitude
Dopaminergic Neurons
ezogabine
Drinking Water
Alcohols
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

The Kv7 potassium channel activator retigabine decreases alcohol consumption in rats. / Knapp, Clifford M.; O'Malley, Matthew; Datta, Subimal; Ciraulo, Domenic A.

In: American Journal of Drug and Alcohol Abuse, Vol. 40, No. 3, 01.01.2014, p. 244-250.

Research output: Contribution to journalArticle

Knapp, Clifford M. ; O'Malley, Matthew ; Datta, Subimal ; Ciraulo, Domenic A. / The Kv7 potassium channel activator retigabine decreases alcohol consumption in rats. In: American Journal of Drug and Alcohol Abuse. 2014 ; Vol. 40, No. 3. pp. 244-250.
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