The localization of projection neurons in the rat hypothalamic paraventricular nucleus following vascular and neurohypophysial injections of HRP

William Armstrong, Glenn I. Hatton

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Projection neurons in the rat hypothalamic paraventricular nucleus (pv) were identified using the retrograde transport of horseradish peroxidase (HRP) following injections of this tracer into the neurohypophysis or jugular vein. The objective was to determine if parvocellular pv neurons might be labelled by either injection in addition to the well known magnocelluLar contingent. Injections confined to the neurohypophysis resulted in the labelling of only magnocellular pv neurons, while intrajugular injections which produced spread of the HRP to the arcuate nucleus-median eminence region resulted in the labelling of both parvocellular and magnocellular pv elements. Thus parvocellular pv neurons may project to the arcuate nucleus and/or the external layer of the median eminance but not to the neurohypophysis.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalBrain Research Bulletin
Volume5
Issue number4
DOIs
StatePublished - Jan 1 1980

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Paraventricular Hypothalamic Nucleus
Horseradish Peroxidase
Posterior Pituitary Gland
Blood Vessels
Neurons
Arcuate Nucleus of Hypothalamus
Injections
Median Eminence
Jugular Veins

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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abstract = "Projection neurons in the rat hypothalamic paraventricular nucleus (pv) were identified using the retrograde transport of horseradish peroxidase (HRP) following injections of this tracer into the neurohypophysis or jugular vein. The objective was to determine if parvocellular pv neurons might be labelled by either injection in addition to the well known magnocelluLar contingent. Injections confined to the neurohypophysis resulted in the labelling of only magnocellular pv neurons, while intrajugular injections which produced spread of the HRP to the arcuate nucleus-median eminence region resulted in the labelling of both parvocellular and magnocellular pv elements. Thus parvocellular pv neurons may project to the arcuate nucleus and/or the external layer of the median eminance but not to the neurohypophysis.",
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