The macrocyclization reaction of terminal dibromoalkanes with sulfide on alumina. The use of a solid support as an alternative to the high dilution technique.

Lay Choo Tan, Richard M. Pagni, George Kabalka, Marc Hillmyer, Julie Woosley

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The reaction of a series of terminal dibromoalkanes with S-2 on Al2O3 has been examined. The use of a solid support for the macrocyclization represents a viable alternate procedure to the more traditional high dilution technique in solution. The cyclizations also occur with thioacetamide on unactivated alumina.

Original languageEnglish (US)
Pages (from-to)7709-7712
Number of pages4
JournalTetrahedron Letters
Volume33
Issue number50
DOIs
StatePublished - Dec 8 1993

Fingerprint

Thioacetamide
Indicator Dilution Techniques
Aluminum Oxide
Cyclization
Sulfides
Dilution

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

The macrocyclization reaction of terminal dibromoalkanes with sulfide on alumina. The use of a solid support as an alternative to the high dilution technique. / Choo Tan, Lay; Pagni, Richard M.; Kabalka, George; Hillmyer, Marc; Woosley, Julie.

In: Tetrahedron Letters, Vol. 33, No. 50, 08.12.1993, p. 7709-7712.

Research output: Contribution to journalArticle

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