The major types of experimentally induced hypertension

Research output: Contribution to journalReview article

Abstract

Human hypertension is a complex and multifactorial disease resulting from the interaction of multiple genetic and environmental factors. Animal models of hypertension have been proved to be useful to study the pathogenesis of, and to find a therapy for, hypertension. The aim of this review is to summarize the most widely used rodent models of experimental hypertension, including advantages and limitations. These models are classified as pharmacologically induced, genetically induced, renal-induced, and environmentally induced hypertension according to the way of induction. The typical representatives of each of these major types of experimental hypertension are desoxycorticosterone acetate-salt-induced hypertension, spontaneous hypertension, renal-induced hypertension, and cold-induced hypertension, respectively. The processes of induction of hypertension, possible pathogenesis, characteristics, advantages, and limitations of the above specific models are reviewed. The clinical significance of each of the above animal models of hypertension is also discussed.

Original languageEnglish (US)
Pages (from-to)191-196
Number of pages6
JournalCardiovascular Reviews and Reports
Volume24
Issue number4
StatePublished - Apr 1 2003

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Hypertension
Animal Models
Desoxycorticosterone Acetate
Renal Hypertension
Rodentia
Theoretical Models
Salts
Kidney

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

The major types of experimentally induced hypertension. / Sun, Zhongjie.

In: Cardiovascular Reviews and Reports, Vol. 24, No. 4, 01.04.2003, p. 191-196.

Research output: Contribution to journalReview article

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