The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity

Tongjian You, Barbara J. Nicklas, Jingzhong Ding, Brenda W.J.H. Penninx, Bret H. Goodpaster, Douglas C. Bauer, Frances Tylavsky, Tamara B. Harris, Stephen B. Kritchevsky

Research output: Contribution to journalArticle

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Abstract

Background. Circulating levels of adipokines are elevated with adiposity and are closely linked with the clustering of traditional metabolic risk factors for cardiovascular disease. The purpose of this study was to examine the relationship of metabolic syndrome to several adipokines and the role of total and visceral adiposity in influencing this relationship in older adults. Methods. A cross-sectional analysis was conducted including 1914 individuals aged 70-79 years without cardiovascular disease or type 2 diabetes. The metabolic syndrome was defined by the updated Adult Treatment Panel III criteria. Circulating levels of leptin, adiponectin, plasminogen activator inhibitor type 1 (PAI-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) were measured. Body composition and abdominal visceral fat area were determined. Results. Both the presence of metabolic syndrome and the number of metabolic syndrome components were associated with higher levels of leptin, PAI-1, IL-6, TNF-α, and CRP and with lower levels of adiponectin (all p < .0001). The odds ratios for the prevalence of metabolic syndrome associated with adipokines were attenuated after adjustment for total fat mass and/or visceral fat area, but remained significant. Levels of leptin, PAI-1, IL-6, and TNF-α were higher (all p < .05 to p < .0001), and adiponectin was lower (all p < .0001), in persons with, compared to those without, metabolic syndrome within each tertile of percent body fat. Conclusion. The metabolic syndrome is associated with adipokines in older adults across a wide range of adiposity, including in those with low or normal overall fatness.

Original languageEnglish (US)
Pages (from-to)414-419
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume63
Issue number4
DOIs
StatePublished - Jan 1 2008

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Adipokines
Adiposity
Adiponectin
Plasminogen Activator Inhibitor 1
Lymphotoxin-beta
Leptin
Interleukin-6
Intra-Abdominal Fat
C-Reactive Protein
Cardiovascular Diseases
Body Composition
Type 2 Diabetes Mellitus
Cluster Analysis
Adipose Tissue
Tumor Necrosis Factor-alpha
Cross-Sectional Studies
Fats
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

Cite this

The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity. / You, Tongjian; Nicklas, Barbara J.; Ding, Jingzhong; Penninx, Brenda W.J.H.; Goodpaster, Bret H.; Bauer, Douglas C.; Tylavsky, Frances; Harris, Tamara B.; Kritchevsky, Stephen B.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 63, No. 4, 01.01.2008, p. 414-419.

Research output: Contribution to journalArticle

You, Tongjian ; Nicklas, Barbara J. ; Ding, Jingzhong ; Penninx, Brenda W.J.H. ; Goodpaster, Bret H. ; Bauer, Douglas C. ; Tylavsky, Frances ; Harris, Tamara B. ; Kritchevsky, Stephen B. / The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2008 ; Vol. 63, No. 4. pp. 414-419.
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abstract = "Background. Circulating levels of adipokines are elevated with adiposity and are closely linked with the clustering of traditional metabolic risk factors for cardiovascular disease. The purpose of this study was to examine the relationship of metabolic syndrome to several adipokines and the role of total and visceral adiposity in influencing this relationship in older adults. Methods. A cross-sectional analysis was conducted including 1914 individuals aged 70-79 years without cardiovascular disease or type 2 diabetes. The metabolic syndrome was defined by the updated Adult Treatment Panel III criteria. Circulating levels of leptin, adiponectin, plasminogen activator inhibitor type 1 (PAI-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) were measured. Body composition and abdominal visceral fat area were determined. Results. Both the presence of metabolic syndrome and the number of metabolic syndrome components were associated with higher levels of leptin, PAI-1, IL-6, TNF-α, and CRP and with lower levels of adiponectin (all p < .0001). The odds ratios for the prevalence of metabolic syndrome associated with adipokines were attenuated after adjustment for total fat mass and/or visceral fat area, but remained significant. Levels of leptin, PAI-1, IL-6, and TNF-α were higher (all p < .05 to p < .0001), and adiponectin was lower (all p < .0001), in persons with, compared to those without, metabolic syndrome within each tertile of percent body fat. Conclusion. The metabolic syndrome is associated with adipokines in older adults across a wide range of adiposity, including in those with low or normal overall fatness.",
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T1 - The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity

AU - You, Tongjian

AU - Nicklas, Barbara J.

AU - Ding, Jingzhong

AU - Penninx, Brenda W.J.H.

AU - Goodpaster, Bret H.

AU - Bauer, Douglas C.

AU - Tylavsky, Frances

AU - Harris, Tamara B.

AU - Kritchevsky, Stephen B.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Background. Circulating levels of adipokines are elevated with adiposity and are closely linked with the clustering of traditional metabolic risk factors for cardiovascular disease. The purpose of this study was to examine the relationship of metabolic syndrome to several adipokines and the role of total and visceral adiposity in influencing this relationship in older adults. Methods. A cross-sectional analysis was conducted including 1914 individuals aged 70-79 years without cardiovascular disease or type 2 diabetes. The metabolic syndrome was defined by the updated Adult Treatment Panel III criteria. Circulating levels of leptin, adiponectin, plasminogen activator inhibitor type 1 (PAI-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) were measured. Body composition and abdominal visceral fat area were determined. Results. Both the presence of metabolic syndrome and the number of metabolic syndrome components were associated with higher levels of leptin, PAI-1, IL-6, TNF-α, and CRP and with lower levels of adiponectin (all p < .0001). The odds ratios for the prevalence of metabolic syndrome associated with adipokines were attenuated after adjustment for total fat mass and/or visceral fat area, but remained significant. Levels of leptin, PAI-1, IL-6, and TNF-α were higher (all p < .05 to p < .0001), and adiponectin was lower (all p < .0001), in persons with, compared to those without, metabolic syndrome within each tertile of percent body fat. Conclusion. The metabolic syndrome is associated with adipokines in older adults across a wide range of adiposity, including in those with low or normal overall fatness.

AB - Background. Circulating levels of adipokines are elevated with adiposity and are closely linked with the clustering of traditional metabolic risk factors for cardiovascular disease. The purpose of this study was to examine the relationship of metabolic syndrome to several adipokines and the role of total and visceral adiposity in influencing this relationship in older adults. Methods. A cross-sectional analysis was conducted including 1914 individuals aged 70-79 years without cardiovascular disease or type 2 diabetes. The metabolic syndrome was defined by the updated Adult Treatment Panel III criteria. Circulating levels of leptin, adiponectin, plasminogen activator inhibitor type 1 (PAI-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and C-reactive protein (CRP) were measured. Body composition and abdominal visceral fat area were determined. Results. Both the presence of metabolic syndrome and the number of metabolic syndrome components were associated with higher levels of leptin, PAI-1, IL-6, TNF-α, and CRP and with lower levels of adiponectin (all p < .0001). The odds ratios for the prevalence of metabolic syndrome associated with adipokines were attenuated after adjustment for total fat mass and/or visceral fat area, but remained significant. Levels of leptin, PAI-1, IL-6, and TNF-α were higher (all p < .05 to p < .0001), and adiponectin was lower (all p < .0001), in persons with, compared to those without, metabolic syndrome within each tertile of percent body fat. Conclusion. The metabolic syndrome is associated with adipokines in older adults across a wide range of adiposity, including in those with low or normal overall fatness.

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