The modulatory role of taurine in retinal ganglion cells

Zheng Jiang, Simon Bulley, Joseph Guzzone, Harris Ripps, Wen Shen

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

Taurine (2-aminoethylsuphonic acid) is present in nearly all animal tissues, and is the most abundant free amino acid in muscle, heart, CNS, and retina. Although it is known to be a major cytoprotectant and essential for normal retinal development, its role in retinal neurotransmission and modulation is not well understood. We investigated the response of taurine in retinal ganglion cells, and its effect on synaptic transmission between ganglion cells and their presynaptic neurons. We fi nd that taurine-elicited currents in ganglion cells could be fully blocked by both strychnine and SR95531, glycine and GABAA receptor antagonists, respectively. This suggests that taurine-activated receptors might share the antagonists with GABA and glycine receptors. The effect of taurine at micromolar concentrations can effectively suppress spontaneous vesicle release from the presynaptic neurons, but had limited effects on light-evoked synaptic signals in ganglion cells. We also describe a metabotropic effect of taurine in the suppression of light-evoked response in ganglion cells. Clearly, taurine acts in multiple ways to modulate synaptic signals in retinal output neurons, ganglion cells.

Original languageEnglish (US)
Title of host publicationTaurine 8
Subtitle of host publicationVolume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System
PublisherSpringer New York LLC
Pages53-68
Number of pages16
ISBN (Print)9781461461296
DOIs
StatePublished - Jan 1 2013

Publication series

NameAdvances in Experimental Medicine and Biology
Volume775
ISSN (Print)0065-2598

Fingerprint

Retinal Ganglion Cells
Taurine
Ganglia
Glycine Receptors
Neurons
Synaptic Transmission
Retinal Neurons
GABA-A Receptor Antagonists
Light
GABA Receptors
Retina
Myocardium
Muscle
Animals
Amino Acids
Modulation
Acids
Tissue

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Jiang, Z., Bulley, S., Guzzone, J., Ripps, H., & Shen, W. (2013). The modulatory role of taurine in retinal ganglion cells. In Taurine 8: Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System (pp. 53-68). (Advances in Experimental Medicine and Biology; Vol. 775). Springer New York LLC. https://doi.org/10.1007/978-1-4614-6130-2_5

The modulatory role of taurine in retinal ganglion cells. / Jiang, Zheng; Bulley, Simon; Guzzone, Joseph; Ripps, Harris; Shen, Wen.

Taurine 8: Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System. Springer New York LLC, 2013. p. 53-68 (Advances in Experimental Medicine and Biology; Vol. 775).

Research output: Chapter in Book/Report/Conference proceedingChapter

Jiang, Z, Bulley, S, Guzzone, J, Ripps, H & Shen, W 2013, The modulatory role of taurine in retinal ganglion cells. in Taurine 8: Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System. Advances in Experimental Medicine and Biology, vol. 775, Springer New York LLC, pp. 53-68. https://doi.org/10.1007/978-1-4614-6130-2_5
Jiang Z, Bulley S, Guzzone J, Ripps H, Shen W. The modulatory role of taurine in retinal ganglion cells. In Taurine 8: Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System. Springer New York LLC. 2013. p. 53-68. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4614-6130-2_5
Jiang, Zheng ; Bulley, Simon ; Guzzone, Joseph ; Ripps, Harris ; Shen, Wen. / The modulatory role of taurine in retinal ganglion cells. Taurine 8: Volume 1: The Nervous System, Immune System, Diabetes and the Cardiovascular System. Springer New York LLC, 2013. pp. 53-68 (Advances in Experimental Medicine and Biology).
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