The morphometry of materno-fetal oxygen exchange barrier in a baboon model of obesity

Jacques Samson, Giancarlo Mari, E. J. Dick, G. B. Hubbard, R. J. Ferry, N. E. Schlabritz-Loutsevitch

Research output: Contribution to journalArticle

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Abstract

Introduction: More than one-fourth of U.S. women are overweight; more than one-third are obese. Maternal obesity has been linked to an increased incidence of stillbirths, fetal macrosomia, fetal intrauterine growth restriction and pre-eclampsia. The placenta plays a key role in the nutrients and oxygen supply to the fetus. The data about structural changes in the placental villous membrane (VM), a major component of the feto-maternal nutrient and oxygen exchange barrier, during obesity are sparse and inconsistent. Our objective was to evaluate the morphometric changes in the placental exchange barrier in a baboon model of obesity. Materials and methods: The previously described baboon model of maternal obesity was studied. We compared 4 obese to 4 non-obese baboons. Placental stereology with the use of transmission electron microscopy was performed to estimate VM oxygen diffusing capacities and morphometry. Results: The specific placental oxygen diffusing capacities per unit of fetal weight were similar in baboons and humans. Maternal leptin concentrations correlated negatively with placental basement membrane thickness (r = -0.78, p < 0.05), while fetal leptin levels correlated negatively with endothelial thickness of fetal capillaries (r = -0.78, p < 0.05). The total and specific villous membrane oxygen diffusing capacities were not different between the two groups. Conclusion: To the best of our knowledge this is the first report of placental oxygen diffusing capacities and placental ultrastructural changes in a baboon model of obesity. Previously reported placental inflammation in maternal obesity is not associated with changes in the VM diffusing capacities and ultrastructure.

Original languageEnglish (US)
Pages (from-to)845-851
Number of pages7
JournalPlacenta
Volume32
Issue number11
DOIs
StatePublished - Nov 1 2011

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Papio
Obesity
Oxygen
Mothers
Membranes
Leptin
Fetal Macrosomia
Food
Fetal Weight
Stillbirth
Fetal Development
Pre-Eclampsia
Transmission Electron Microscopy
Basement Membrane
Placenta
Fetus
Inflammation
Incidence

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology
  • Reproductive Medicine
  • Developmental Biology

Cite this

Samson, J., Mari, G., Dick, E. J., Hubbard, G. B., Ferry, R. J., & Schlabritz-Loutsevitch, N. E. (2011). The morphometry of materno-fetal oxygen exchange barrier in a baboon model of obesity. Placenta, 32(11), 845-851. https://doi.org/10.1016/j.placenta.2011.07.083

The morphometry of materno-fetal oxygen exchange barrier in a baboon model of obesity. / Samson, Jacques; Mari, Giancarlo; Dick, E. J.; Hubbard, G. B.; Ferry, R. J.; Schlabritz-Loutsevitch, N. E.

In: Placenta, Vol. 32, No. 11, 01.11.2011, p. 845-851.

Research output: Contribution to journalArticle

Samson, J, Mari, G, Dick, EJ, Hubbard, GB, Ferry, RJ & Schlabritz-Loutsevitch, NE 2011, 'The morphometry of materno-fetal oxygen exchange barrier in a baboon model of obesity', Placenta, vol. 32, no. 11, pp. 845-851. https://doi.org/10.1016/j.placenta.2011.07.083
Samson, Jacques ; Mari, Giancarlo ; Dick, E. J. ; Hubbard, G. B. ; Ferry, R. J. ; Schlabritz-Loutsevitch, N. E. / The morphometry of materno-fetal oxygen exchange barrier in a baboon model of obesity. In: Placenta. 2011 ; Vol. 32, No. 11. pp. 845-851.
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