The navigation guide—evidence-based medicine meets environmental health

Systematic review of nonhuman evidence for PFOA effects on fetal growth

Erica Koustas, Juleen Lam, Patrice Sutton, Paula I. Johnson, Dylan S. Atchley, Saunak Sen, Karen A. Robinson, Daniel A. Axelrad, Tracey J. Woodruff

Research output: Contribution to journalReview article

69 Citations (Scopus)

Abstract

Results: Twenty-one studies met the inclusion criteria. From the meta-analysis of eight mouse gavage data sets, we estimated that exposure of pregnant mice to increasing concentrations of PFOA was associated with a change in mean pup birth weight of –0.023 g (95% CI: –0.029, –0.016) per 1-unit increase in dose (milligrams per kilogram body weight per day). The evidence, consisting of 15 mammalian and 6 nonmammalianstudies, was rated as “moderate” and “low” quality, respectively.

Background: In contrast to current methods of expert-based narrative review, the Navigation Guide is a systematic and transparent method for synthesizing environmental health research from multiple evidence streams. The Navigation Guide was developed to effectively and efficiently translate the available scientific evidence into timely prevention-oriented action.

Objectives: We applied the Navigation Guide systematic review method to answer the question “Does fetal developmental exposure to perfluorooctanoic acid (PFOA) or its salts affect fetal growth in animals ?” and to rate the strength of the experimental animal evidence.

Methods: We conducted a comprehensive search of the literature, applied prespecified criteria to the search results to identify relevant studies, extracted data from studies, obtained additional informationfrom study authors, conducted meta-analyses, and rated the overall quality and strength of the evidence.

Conclusion: Based on this first application of the Navigation Guide methodology, we found sufficient evidence that fetal developmental exposure to PFOA reduces fetal growth in animals.

Original languageEnglish (US)
Pages (from-to)1015-1027
Number of pages13
JournalEnvironmental Health Perspectives
Volume122
Issue number10
DOIs
StatePublished - Oct 1 2014

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perfluorooctanoic acid
Environmental Health
Fetal Development
Medicine
Meta-Analysis
Birth Weight
Salts
Body Weight
Research

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Cite this

The navigation guide—evidence-based medicine meets environmental health : Systematic review of nonhuman evidence for PFOA effects on fetal growth. / Koustas, Erica; Lam, Juleen; Sutton, Patrice; Johnson, Paula I.; Atchley, Dylan S.; Sen, Saunak; Robinson, Karen A.; Axelrad, Daniel A.; Woodruff, Tracey J.

In: Environmental Health Perspectives, Vol. 122, No. 10, 01.10.2014, p. 1015-1027.

Research output: Contribution to journalReview article

Koustas, Erica ; Lam, Juleen ; Sutton, Patrice ; Johnson, Paula I. ; Atchley, Dylan S. ; Sen, Saunak ; Robinson, Karen A. ; Axelrad, Daniel A. ; Woodruff, Tracey J. / The navigation guide—evidence-based medicine meets environmental health : Systematic review of nonhuman evidence for PFOA effects on fetal growth. In: Environmental Health Perspectives. 2014 ; Vol. 122, No. 10. pp. 1015-1027.
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