The neuronal code(s) of the cerebellum

Detlef Heck, Chris I. De Zeeuw, Dieter Jaeger, Kamran Khodakhah, Abigail L. Person

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Understanding how neurons encode information in sequences of action potentials is of fundamental importance to neuroscience. The cerebellum is widely recognized for its involvement in the coordination of movements, which requires muscle activation patterns to be controlled with millisecond precision. Understanding how cerebellar neurons accomplish such high temporal precision is critical to understanding cerebellar function. Inhibitory Purkinje cells, the only output neurons of the cerebellar cortex, and their postsynaptic target neurons in the cerebellar nuclei, fire action potentials at high, sustained frequencies, suggesting spike rate modulation as a possible code. Yet, millisecond precise spatiotemporal spike activity patterns in Purkinje cells and inferior olivary neurons have also been observed. These results and ongoing studies suggest that the neuronal code used by cerebellar neurons may span a wide time scale from millisecond precision to slow rate modulations, likely depending on the behavioral context.

Original languageEnglish (US)
Pages (from-to)17603-17609
Number of pages7
JournalJournal of Neuroscience
Volume33
Issue number45
DOIs
StatePublished - Nov 11 2013

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Cerebellum
Neurons
Purkinje Cells
Action Potentials
Cerebellar Nuclei
Cerebellar Cortex
Neurosciences
Muscles

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Heck, D., De Zeeuw, C. I., Jaeger, D., Khodakhah, K., & Person, A. L. (2013). The neuronal code(s) of the cerebellum. Journal of Neuroscience, 33(45), 17603-17609. https://doi.org/10.1523/JNEUROSCI.2759-13.2013

The neuronal code(s) of the cerebellum. / Heck, Detlef; De Zeeuw, Chris I.; Jaeger, Dieter; Khodakhah, Kamran; Person, Abigail L.

In: Journal of Neuroscience, Vol. 33, No. 45, 11.11.2013, p. 17603-17609.

Research output: Contribution to journalArticle

Heck, D, De Zeeuw, CI, Jaeger, D, Khodakhah, K & Person, AL 2013, 'The neuronal code(s) of the cerebellum', Journal of Neuroscience, vol. 33, no. 45, pp. 17603-17609. https://doi.org/10.1523/JNEUROSCI.2759-13.2013
Heck D, De Zeeuw CI, Jaeger D, Khodakhah K, Person AL. The neuronal code(s) of the cerebellum. Journal of Neuroscience. 2013 Nov 11;33(45):17603-17609. https://doi.org/10.1523/JNEUROSCI.2759-13.2013
Heck, Detlef ; De Zeeuw, Chris I. ; Jaeger, Dieter ; Khodakhah, Kamran ; Person, Abigail L. / The neuronal code(s) of the cerebellum. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 45. pp. 17603-17609.
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