The optimization of dose delivery for intraoperative high-dose-rate radiation therapy using curved HAM applicators

A. Sam Beddar, Sunil Krishnan, Tina M. Briere, Xiaochun Wang, Marc E. Delclos, Matthew Ballo, Prajnan Das, Spencer Gould, John L. Horton, Christopher H. Crane

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background and purpose: To determine the effect of the curvature of Harrison-Anderson-Mick applicators on the dose distribution in high-dose-rate intraoperative radiation therapy (HDR-IORT). Material and methods: Treatment planning was performed with flat applicators using 192Ir as the radioactive source, and dwell times were optimized using dose-point optimization techniques. These optimized dwell times were then used for the curved applicators, and the dose distributions that would actually be delivered to patients were determined. Results: The dose directly below the central catheter was strongly dependent on the curvature of the applicator. Steep parabolic curves caused underdoses of as much as 19% at a point 1 cm from the convex side of the applicator. The rate of dose reduction with increasing distance from the applicator surface was also a function of the curvature of the applicator. Conclusions: The curvature of the applicator profoundly affects dosimetry and can be exploited to optimize coverage of the target during HDR-IORT procedures. To ensure accurate dose delivery, these dose perturbations must be accounted for in the planning process. We recommend maintaining a dosimetry atlas of various applicator sizes and curvatures in addition to one for flat applicators.

Original languageEnglish (US)
Pages (from-to)207-212
Number of pages6
JournalRadiotherapy and Oncology
Volume78
Issue number2
DOIs
StatePublished - Feb 1 2006

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Radiotherapy
Atlases
Catheters
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

The optimization of dose delivery for intraoperative high-dose-rate radiation therapy using curved HAM applicators. / Beddar, A. Sam; Krishnan, Sunil; Briere, Tina M.; Wang, Xiaochun; Delclos, Marc E.; Ballo, Matthew; Das, Prajnan; Gould, Spencer; Horton, John L.; Crane, Christopher H.

In: Radiotherapy and Oncology, Vol. 78, No. 2, 01.02.2006, p. 207-212.

Research output: Contribution to journalArticle

Beddar, AS, Krishnan, S, Briere, TM, Wang, X, Delclos, ME, Ballo, M, Das, P, Gould, S, Horton, JL & Crane, CH 2006, 'The optimization of dose delivery for intraoperative high-dose-rate radiation therapy using curved HAM applicators', Radiotherapy and Oncology, vol. 78, no. 2, pp. 207-212. https://doi.org/10.1016/j.radonc.2005.11.013
Beddar, A. Sam ; Krishnan, Sunil ; Briere, Tina M. ; Wang, Xiaochun ; Delclos, Marc E. ; Ballo, Matthew ; Das, Prajnan ; Gould, Spencer ; Horton, John L. ; Crane, Christopher H. / The optimization of dose delivery for intraoperative high-dose-rate radiation therapy using curved HAM applicators. In: Radiotherapy and Oncology. 2006 ; Vol. 78, No. 2. pp. 207-212.
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AU - Krishnan, Sunil

AU - Briere, Tina M.

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AU - Delclos, Marc E.

AU - Ballo, Matthew

AU - Das, Prajnan

AU - Gould, Spencer

AU - Horton, John L.

AU - Crane, Christopher H.

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