The P450 Superfamily

Update on New Sequences, Gene Mapping, and Recommended Nomenclature

Daniel W. Nebert, David Nelson, Minor J. Coon, Ronald W. Estabrook, Rene Feyereisen, Yoshiaki Fujii-Kuriyama, Frank J. Gonzalez, F. Peter Guengerich, Irwin C. Gunsalus, Eric F. Johnson, John C. Loper, Ryo Sato, Michael R. Waterman, David J. Waxman

Research output: Contribution to journalArticle

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Abstract

We provide here a list of 154 P450 genes and seven putative pseudogenes that have been characterized as of October 20, 1990. These genes have been described in a total of 23 eukaryotes (including nine mammalian and one plant species) and six prokaryotes. Of 27 gene families so far described, 10 exist in all mammals. These 10 families comprise 18 subfamilies, of which 16 and 14 have been mapped in the human and mouse genomes, respectively; to date, each subfamily appears to represent a cluster of tightly linked genes. We propose here a modest revision of the initially proposed (Nebert et al., DNA 6, 1–11,1987) and updated (Nebert et al., DNA 8, 1–13, 1989) nomenclature system based on evolution of the superfamily. For the gene we recommend that the italicized root symbol CYP for human (Cyp for mouse), representing cytochrome P450, be followed by an Arabic number denoting the family, a letter designating the subfamily (when two or more exist), and an Arabic numeral representing the individual gene within the subfamily. A hyphen should precede the final number in mouse genes. We suggest that the human nomenclature system be used for other species. This system is consistent with our earlier proposed nomenclature for P450 of all eukaryotes and prokaryotes, except that we are discouraging the future use of cumbersome Roman numerals.

Original languageEnglish (US)
Pages (from-to)1-14
Number of pages14
JournalDNA and Cell Biology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 1991

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Chromosome Mapping
Terminology
Genes
Eukaryota
Pseudogenes
DNA
Human Genome
Cytochrome P-450 Enzyme System
Mammals

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Nebert, D. W., Nelson, D., Coon, M. J., Estabrook, R. W., Feyereisen, R., Fujii-Kuriyama, Y., ... Waxman, D. J. (1991). The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature. DNA and Cell Biology, 10(1), 1-14. https://doi.org/10.1089/dna.1991.10.1

The P450 Superfamily : Update on New Sequences, Gene Mapping, and Recommended Nomenclature. / Nebert, Daniel W.; Nelson, David; Coon, Minor J.; Estabrook, Ronald W.; Feyereisen, Rene; Fujii-Kuriyama, Yoshiaki; Gonzalez, Frank J.; Guengerich, F. Peter; Gunsalus, Irwin C.; Johnson, Eric F.; Loper, John C.; Sato, Ryo; Waterman, Michael R.; Waxman, David J.

In: DNA and Cell Biology, Vol. 10, No. 1, 01.01.1991, p. 1-14.

Research output: Contribution to journalArticle

Nebert, DW, Nelson, D, Coon, MJ, Estabrook, RW, Feyereisen, R, Fujii-Kuriyama, Y, Gonzalez, FJ, Guengerich, FP, Gunsalus, IC, Johnson, EF, Loper, JC, Sato, R, Waterman, MR & Waxman, DJ 1991, 'The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature', DNA and Cell Biology, vol. 10, no. 1, pp. 1-14. https://doi.org/10.1089/dna.1991.10.1
Nebert, Daniel W. ; Nelson, David ; Coon, Minor J. ; Estabrook, Ronald W. ; Feyereisen, Rene ; Fujii-Kuriyama, Yoshiaki ; Gonzalez, Frank J. ; Guengerich, F. Peter ; Gunsalus, Irwin C. ; Johnson, Eric F. ; Loper, John C. ; Sato, Ryo ; Waterman, Michael R. ; Waxman, David J. / The P450 Superfamily : Update on New Sequences, Gene Mapping, and Recommended Nomenclature. In: DNA and Cell Biology. 1991 ; Vol. 10, No. 1. pp. 1-14.
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