The P450 Superfamily

Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci

Daniel W. Nebert, David Nelson, Milton Adesnik, Minor J. Coon, Ronald W. Estabrook, Frank J. Gonzalez, F. Peter Guengerich, Irwin C. Gunsalus, Eric F. Johnson, Byron Kemper, Wayne Levin, Ian R. Phillips, Ryo Sato, Michael R. Waterman

Research output: Contribution to journalArticle

531 Citations (Scopus)

Abstract

In this update we provide a list of the 71 P450 genes and the four P450 pseudogenes that have been characterized as of September 30, 1988. The chromosomal locations of many of these genes are also summarized. A modest revision of the initially proposed nomenclature of the P450 superfamily (Nebert et al., DNA 6, 1–11, 1987) is described specifically for the human and mouse chromosomal loci. The motivation for this revision is to conform to the rules of nomenclature for human and mouse genes. Recommendations for the naming of chromosomal loci include the root symbol “CYP” for human (“Cyp” for mouse), denoting “cytochrome P450.” We recommend that this root also be used for other organisms. For a chromosomal locus, the root symbol is followed by an Arabic numeral designating the P450 family, a letter indicating the sub-family, and an Arabic numeral representing the individual gene within the family or subfamily. Numbers of the individual genes usually will be assigned in the order the genes are identified. This system is consistent with our earlier proposed nomenclature for P450 families and gene products from all eukaryotes and prokaryotes.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalDNA
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1989

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Terminology
Genes
Pseudogenes
Gene Order
Eukaryota
Cytochrome P-450 Enzyme System
DNA

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Nebert, D. W., Nelson, D., Adesnik, M., Coon, M. J., Estabrook, R. W., Gonzalez, F. J., ... Waterman, M. R. (1989). The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci. DNA, 8(1), 1-13. https://doi.org/10.1089/dna.1.1989.8.1

The P450 Superfamily : Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci. / Nebert, Daniel W.; Nelson, David; Adesnik, Milton; Coon, Minor J.; Estabrook, Ronald W.; Gonzalez, Frank J.; Guengerich, F. Peter; Gunsalus, Irwin C.; Johnson, Eric F.; Kemper, Byron; Levin, Wayne; Phillips, Ian R.; Sato, Ryo; Waterman, Michael R.

In: DNA, Vol. 8, No. 1, 01.01.1989, p. 1-13.

Research output: Contribution to journalArticle

Nebert, DW, Nelson, D, Adesnik, M, Coon, MJ, Estabrook, RW, Gonzalez, FJ, Guengerich, FP, Gunsalus, IC, Johnson, EF, Kemper, B, Levin, W, Phillips, IR, Sato, R & Waterman, MR 1989, 'The P450 Superfamily: Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci', DNA, vol. 8, no. 1, pp. 1-13. https://doi.org/10.1089/dna.1.1989.8.1
Nebert, Daniel W. ; Nelson, David ; Adesnik, Milton ; Coon, Minor J. ; Estabrook, Ronald W. ; Gonzalez, Frank J. ; Guengerich, F. Peter ; Gunsalus, Irwin C. ; Johnson, Eric F. ; Kemper, Byron ; Levin, Wayne ; Phillips, Ian R. ; Sato, Ryo ; Waterman, Michael R. / The P450 Superfamily : Updated Listing of All Genes and Recommended Nomenclature for the Chromosomal Loci. In: DNA. 1989 ; Vol. 8, No. 1. pp. 1-13.
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