The pericardium and ventricular interaction, distensibility, and function

J. S. Janicki, Karl Weber

Research output: Contribution to journalArticle

162 Citations (Scopus)

Abstract

To examine the influence of the pericardium on distensibility, function, and mechanical interaction of the left (LV) and right (RV) ventricles, 15 isolated canine hearts were studied with and without the pericardium. Over the end-diastolic pressure range 0-20 mmHg the following relationships were assessed in each ventricle before and after pericardiectomy: a) RV and LV end-diastolic pressure (EDP)-volume (EDV) curves (distensibility); b) RV and LV peak developed isovolumetric pressure (DP)-EDV curves (systolic function); and c) the influence of varying the chamber size of one ventricle on the EDP (diastolic interaction) and DP (systolic interaction) of the other ventricle. For both ventricles, pericardiectomy resulted in a significant decrease (P < 0.05) in EDP and in the degree of diastolic interaction at any given EDV over the 0-20 mmHg range of filling pressures examined, the decline in EDP being dependent on the absolute level of EDV. Reductions in DP and in the degree of systolic interaction were also noted following pericardiectomy; however, only the decrease in RVDP was significant (P < 0.05). Thus the pericardium serves to influence the distensibility of each ventricle and enhances the mechanical interaction between ventricles during diastole. The systolic performance of the right ventricle is augmented by the presence of the pericardium, but its influence on left ventricular function is more variable.

Original languageEnglish (US)
Pages (from-to)494-503
Number of pages10
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume7
Issue number4
StatePublished - Jan 1 1980
Externally publishedYes

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Pericardium
Pericardiectomy
Blood Pressure
Pressure
Heart Ventricles
Diastole
Left Ventricular Function
Canidae

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

The pericardium and ventricular interaction, distensibility, and function. / Janicki, J. S.; Weber, Karl.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 7, No. 4, 01.01.1980, p. 494-503.

Research output: Contribution to journalArticle

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