THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l‐DOPA OR d‐AMPHETAMINE

M. A. Moskowitz, Deborah Rubin, J. Liebschutz, H. N. Munro, Thaddeus Nowak, R. J. Wurtman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Abstract— l‐DOPA or d‐amphetamine administration disaggregates brain polyribosomes in animals maintained in an environment warm enough (26°C) so that the drugs concurrently elevate their body temperatures to above 39°C. The production of equivalent hyperthermia (by keeping control rats at ambient temperatures of 40–44° C) does not cause similar disaggregation of brain polysomes. Hence, the role of hyperthermia in the drug‐induced disaggregation is permissive.

Original languageEnglish (US)
Pages (from-to)779-782
Number of pages4
JournalJournal of Neurochemistry
Volume28
Issue number4
DOIs
StatePublished - Jan 1 1977

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Polyribosomes
Brain
Fever
Rat control
Body Temperature
Animals
Temperature
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l‐DOPA OR d‐AMPHETAMINE. / Moskowitz, M. A.; Rubin, Deborah; Liebschutz, J.; Munro, H. N.; Nowak, Thaddeus; Wurtman, R. J.

In: Journal of Neurochemistry, Vol. 28, No. 4, 01.01.1977, p. 779-782.

Research output: Contribution to journalArticle

Moskowitz, M. A. ; Rubin, Deborah ; Liebschutz, J. ; Munro, H. N. ; Nowak, Thaddeus ; Wurtman, R. J. / THE PERMISSIVE ROLE OF HYPERTHERMIA IN THE DISAGGREGATION OF BRAIN POLYSOMES BY l‐DOPA OR d‐AMPHETAMINE. In: Journal of Neurochemistry. 1977 ; Vol. 28, No. 4. pp. 779-782.
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