The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza

Jonathan Mccullers, Amy R. Iverson, Peter J. Murray

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Pneumonia caused by Streptococcus pneumoniae is a significant cause of morbidity and mortality during influenza virus epidemics. We had previously advanced the hypothesis that interactions of pneumococcus with the receptor for platelet activating factor (PAFR) in the lung were facilitated by antecedent influenza virus infection and play a major role in the pathogenesis of bacterial superinfections. Although influenza enhanced the adherence of pneumococci to respiratory epithelial cells in vitro, chemical or antibody-mediated blockade of the PAFR did not affect adherence. In agreement with these data, mice lacking PAFR had similar bacterial loads within the lung compartment when compared to heterozygous littermates and were not protected from secondary pneumococcal pneumonia after influenza. Lack of support for this hypothesis and the observation of enhanced inflammation during secondary pneumococcal pneumonia in mice lacking PAFR may moderate enthusiasm for treatment strategies targeting the interaction of bacteria with PAFR.

Original languageEnglish (US)
Pages (from-to)11-17
Number of pages7
JournalScandinavian Journal of Infectious Diseases
Volume40
Issue number1
DOIs
StatePublished - Jan 11 2008

Fingerprint

Bacterial Pneumonia
Platelet Activating Factor
Human Influenza
Streptococcus pneumoniae
Pneumococcal Pneumonia
Orthomyxoviridae
Lung
Superinfection
Bacterial Load
Virus Diseases
Pneumonia
Epithelial Cells
Observation
Inflammation
Morbidity
Bacteria
Mortality
platelet activating factor receptor
Antibodies

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza. / Mccullers, Jonathan; Iverson, Amy R.; Murray, Peter J.

In: Scandinavian Journal of Infectious Diseases, Vol. 40, No. 1, 11.01.2008, p. 11-17.

Research output: Contribution to journalArticle

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