The potential of F-18-FDG PET in breast cancer

Detection of primary lesions, axillary lymph node metastases, or distant metastases

Karl Hubner, Gary T. Smith, Joseph A. Thie, John Bell, Henry Nelson, Wahid Hanna

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

This retrospective study was done to evaluate the utility of 2-[F-18]fluoro-2-deoxy-D-glucose positron emission tomography (F-18-FDG PET) in identifying primary and recurrent breast cancer and lymph node metastases. One hundred whole-body PET scans of 87 patients were reviewed. PET results obtained with F-18-FDG and an ECAT/EXACT-921 or an ECAT-931 (Siemens/CTI) were based on visual interpretation, or standardized uptake values (SUVs), related to histology and also compared to computerized tomography (CT) and mammography results. The sensitivity for PET in detecting primary (N = 35 studies) and recurrent breast cancer (N = 65 studies) was 96% and 85% with a specificity of 91% and 73%. The sensitivity for lymph node metastases at the time of initial diagnosis was 100% with a specificity of 100%. Quantitative SUV information did not improve the accuracy of F-18-FDG PET in identifying primary breast cancers. The results suggest that whole-body PET is useful in detecting recurrence or metastases, may be useful in detecting lymph node metastases prior to initial axillary lymph node dissection, but is less sensitive in excluding axillary lymph nodes metastases later in the course of the disease.

Original languageEnglish (US)
Pages (from-to)197-205
Number of pages9
JournalClinical Positron Imaging (Netherlands)
Volume3
Issue number5
DOIs
StatePublished - Jan 1 2000

Fingerprint

Lymph Nodes
Breast Neoplasms
Neoplasm Metastasis
Positron-Emission Tomography
Whole Body Imaging
Deoxyglucose
Mammography
Lymph Node Excision
Histology
Retrospective Studies
Tomography
Recurrence

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

@article{6b7c8442a463404f877f2ed26627b3de,
title = "The potential of F-18-FDG PET in breast cancer: Detection of primary lesions, axillary lymph node metastases, or distant metastases",
abstract = "This retrospective study was done to evaluate the utility of 2-[F-18]fluoro-2-deoxy-D-glucose positron emission tomography (F-18-FDG PET) in identifying primary and recurrent breast cancer and lymph node metastases. One hundred whole-body PET scans of 87 patients were reviewed. PET results obtained with F-18-FDG and an ECAT/EXACT-921 or an ECAT-931 (Siemens/CTI) were based on visual interpretation, or standardized uptake values (SUVs), related to histology and also compared to computerized tomography (CT) and mammography results. The sensitivity for PET in detecting primary (N = 35 studies) and recurrent breast cancer (N = 65 studies) was 96{\%} and 85{\%} with a specificity of 91{\%} and 73{\%}. The sensitivity for lymph node metastases at the time of initial diagnosis was 100{\%} with a specificity of 100{\%}. Quantitative SUV information did not improve the accuracy of F-18-FDG PET in identifying primary breast cancers. The results suggest that whole-body PET is useful in detecting recurrence or metastases, may be useful in detecting lymph node metastases prior to initial axillary lymph node dissection, but is less sensitive in excluding axillary lymph nodes metastases later in the course of the disease.",
author = "Karl Hubner and Smith, {Gary T.} and Thie, {Joseph A.} and John Bell and Henry Nelson and Wahid Hanna",
year = "2000",
month = "1",
day = "1",
doi = "10.1016/S1095-0397(00)00050-9",
language = "English (US)",
volume = "3",
pages = "197--205",
journal = "Molecular Imaging and Biology",
issn = "1536-1632",
publisher = "Springer New York",
number = "5",

}

TY - JOUR

T1 - The potential of F-18-FDG PET in breast cancer

T2 - Detection of primary lesions, axillary lymph node metastases, or distant metastases

AU - Hubner, Karl

AU - Smith, Gary T.

AU - Thie, Joseph A.

AU - Bell, John

AU - Nelson, Henry

AU - Hanna, Wahid

PY - 2000/1/1

Y1 - 2000/1/1

N2 - This retrospective study was done to evaluate the utility of 2-[F-18]fluoro-2-deoxy-D-glucose positron emission tomography (F-18-FDG PET) in identifying primary and recurrent breast cancer and lymph node metastases. One hundred whole-body PET scans of 87 patients were reviewed. PET results obtained with F-18-FDG and an ECAT/EXACT-921 or an ECAT-931 (Siemens/CTI) were based on visual interpretation, or standardized uptake values (SUVs), related to histology and also compared to computerized tomography (CT) and mammography results. The sensitivity for PET in detecting primary (N = 35 studies) and recurrent breast cancer (N = 65 studies) was 96% and 85% with a specificity of 91% and 73%. The sensitivity for lymph node metastases at the time of initial diagnosis was 100% with a specificity of 100%. Quantitative SUV information did not improve the accuracy of F-18-FDG PET in identifying primary breast cancers. The results suggest that whole-body PET is useful in detecting recurrence or metastases, may be useful in detecting lymph node metastases prior to initial axillary lymph node dissection, but is less sensitive in excluding axillary lymph nodes metastases later in the course of the disease.

AB - This retrospective study was done to evaluate the utility of 2-[F-18]fluoro-2-deoxy-D-glucose positron emission tomography (F-18-FDG PET) in identifying primary and recurrent breast cancer and lymph node metastases. One hundred whole-body PET scans of 87 patients were reviewed. PET results obtained with F-18-FDG and an ECAT/EXACT-921 or an ECAT-931 (Siemens/CTI) were based on visual interpretation, or standardized uptake values (SUVs), related to histology and also compared to computerized tomography (CT) and mammography results. The sensitivity for PET in detecting primary (N = 35 studies) and recurrent breast cancer (N = 65 studies) was 96% and 85% with a specificity of 91% and 73%. The sensitivity for lymph node metastases at the time of initial diagnosis was 100% with a specificity of 100%. Quantitative SUV information did not improve the accuracy of F-18-FDG PET in identifying primary breast cancers. The results suggest that whole-body PET is useful in detecting recurrence or metastases, may be useful in detecting lymph node metastases prior to initial axillary lymph node dissection, but is less sensitive in excluding axillary lymph nodes metastases later in the course of the disease.

UR - http://www.scopus.com/inward/record.url?scp=0000918158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0000918158&partnerID=8YFLogxK

U2 - 10.1016/S1095-0397(00)00050-9

DO - 10.1016/S1095-0397(00)00050-9

M3 - Article

VL - 3

SP - 197

EP - 205

JO - Molecular Imaging and Biology

JF - Molecular Imaging and Biology

SN - 1536-1632

IS - 5

ER -