The prognostic significance of lymphopenia in peripheral T-cell and natural killer/T-cell lymphomas

A study of 826 cases from the International Peripheral T-cell Lymphoma Project

Zdravko Mitrovic, Anamarija M. Perry, Junji Suzumiya, James O. Armitage, Wing Y. Au, Bertrand Coiffier, Harald Holte, Elaine S. Jaffe, Emili Monserrat, Sandeep Rajan, Kerry J. Savage, Kensei Tobinai, Julie M. Vose, Dennis D. Weisenburger

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Abstract

Lymphopenia is a marker of inferior survival in patients with various malignancies. However, the prognostic significance of lymphopenia in peripheral T-cell lymphoma (PTCL) is unclear. We analyzed the prognostic significance of lymphopenia in 826 patients with different types of PTCL and natural killer/T-cell lymphoma (NKTCL) from the International Peripheral T-cell Lymphoma Project. Lymphopenia was defined as an absolute lymphocyte count of less than 1,000 cells per microliter. The overall frequency of lymphopenia was 35.3%, ranging from 21.1% in ALK+ anaplastic large cell lymphoma (ALCL) to 47.5% in angioimmunoblastic T-cell lymphoma (AITL). Lymphopenia was independently associated with an inferior overall survival (OS) in patients with the lymphoma type of adult T-cell leukemia/lymphoma (ATLL), with a 2-year OS of 15% versus 40% for those without lymphopenia (P < 0.001). Lymphopenia was also an adverse predictor of survival in PTCL, not otherwise specified, but was associated with other unfavorable prognostic factors. A trend toward inferior survival for lymphopenic patients was also observed in AITL, ALK- ALCL and extranasal NKTCL lymphoma, whereas no difference in survival was found in nasal NKTCL, ALK+ ALCL, or enteropathy-associated T-cell lymphoma. In this study, lymphopenia was identified as a new adverse prognostic factor in the lymphoma type of ATLL.

Original languageEnglish (US)
Pages (from-to)790-794
Number of pages5
JournalAmerican Journal of Hematology
Volume87
Issue number8
DOIs
StatePublished - Jan 1 2012

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Peripheral T-Cell Lymphoma
Lymphopenia
Natural Killer T-Cells
T-Cell Lymphoma
T-Lymphocytes
Anaplastic Large-Cell Lymphoma
Survival
Adult T Cell Leukemia Lymphoma
Lymphoma
Enteropathy-Associated T-Cell Lymphoma
Lymphocyte Count
Nose

All Science Journal Classification (ASJC) codes

  • Hematology

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The prognostic significance of lymphopenia in peripheral T-cell and natural killer/T-cell lymphomas : A study of 826 cases from the International Peripheral T-cell Lymphoma Project. / Mitrovic, Zdravko; Perry, Anamarija M.; Suzumiya, Junji; Armitage, James O.; Au, Wing Y.; Coiffier, Bertrand; Holte, Harald; Jaffe, Elaine S.; Monserrat, Emili; Rajan, Sandeep; Savage, Kerry J.; Tobinai, Kensei; Vose, Julie M.; Weisenburger, Dennis D.

In: American Journal of Hematology, Vol. 87, No. 8, 01.01.2012, p. 790-794.

Research output: Contribution to journalArticle

Mitrovic, Z, Perry, AM, Suzumiya, J, Armitage, JO, Au, WY, Coiffier, B, Holte, H, Jaffe, ES, Monserrat, E, Rajan, S, Savage, KJ, Tobinai, K, Vose, JM & Weisenburger, DD 2012, 'The prognostic significance of lymphopenia in peripheral T-cell and natural killer/T-cell lymphomas: A study of 826 cases from the International Peripheral T-cell Lymphoma Project', American Journal of Hematology, vol. 87, no. 8, pp. 790-794. https://doi.org/10.1002/ajh.23205
Mitrovic, Zdravko ; Perry, Anamarija M. ; Suzumiya, Junji ; Armitage, James O. ; Au, Wing Y. ; Coiffier, Bertrand ; Holte, Harald ; Jaffe, Elaine S. ; Monserrat, Emili ; Rajan, Sandeep ; Savage, Kerry J. ; Tobinai, Kensei ; Vose, Julie M. ; Weisenburger, Dennis D. / The prognostic significance of lymphopenia in peripheral T-cell and natural killer/T-cell lymphomas : A study of 826 cases from the International Peripheral T-cell Lymphoma Project. In: American Journal of Hematology. 2012 ; Vol. 87, No. 8. pp. 790-794.
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abstract = "Lymphopenia is a marker of inferior survival in patients with various malignancies. However, the prognostic significance of lymphopenia in peripheral T-cell lymphoma (PTCL) is unclear. We analyzed the prognostic significance of lymphopenia in 826 patients with different types of PTCL and natural killer/T-cell lymphoma (NKTCL) from the International Peripheral T-cell Lymphoma Project. Lymphopenia was defined as an absolute lymphocyte count of less than 1,000 cells per microliter. The overall frequency of lymphopenia was 35.3{\%}, ranging from 21.1{\%} in ALK+ anaplastic large cell lymphoma (ALCL) to 47.5{\%} in angioimmunoblastic T-cell lymphoma (AITL). Lymphopenia was independently associated with an inferior overall survival (OS) in patients with the lymphoma type of adult T-cell leukemia/lymphoma (ATLL), with a 2-year OS of 15{\%} versus 40{\%} for those without lymphopenia (P < 0.001). Lymphopenia was also an adverse predictor of survival in PTCL, not otherwise specified, but was associated with other unfavorable prognostic factors. A trend toward inferior survival for lymphopenic patients was also observed in AITL, ALK- ALCL and extranasal NKTCL lymphoma, whereas no difference in survival was found in nasal NKTCL, ALK+ ALCL, or enteropathy-associated T-cell lymphoma. In this study, lymphopenia was identified as a new adverse prognostic factor in the lymphoma type of ATLL.",
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T2 - A study of 826 cases from the International Peripheral T-cell Lymphoma Project

AU - Mitrovic, Zdravko

AU - Perry, Anamarija M.

AU - Suzumiya, Junji

AU - Armitage, James O.

AU - Au, Wing Y.

AU - Coiffier, Bertrand

AU - Holte, Harald

AU - Jaffe, Elaine S.

AU - Monserrat, Emili

AU - Rajan, Sandeep

AU - Savage, Kerry J.

AU - Tobinai, Kensei

AU - Vose, Julie M.

AU - Weisenburger, Dennis D.

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N2 - Lymphopenia is a marker of inferior survival in patients with various malignancies. However, the prognostic significance of lymphopenia in peripheral T-cell lymphoma (PTCL) is unclear. We analyzed the prognostic significance of lymphopenia in 826 patients with different types of PTCL and natural killer/T-cell lymphoma (NKTCL) from the International Peripheral T-cell Lymphoma Project. Lymphopenia was defined as an absolute lymphocyte count of less than 1,000 cells per microliter. The overall frequency of lymphopenia was 35.3%, ranging from 21.1% in ALK+ anaplastic large cell lymphoma (ALCL) to 47.5% in angioimmunoblastic T-cell lymphoma (AITL). Lymphopenia was independently associated with an inferior overall survival (OS) in patients with the lymphoma type of adult T-cell leukemia/lymphoma (ATLL), with a 2-year OS of 15% versus 40% for those without lymphopenia (P < 0.001). Lymphopenia was also an adverse predictor of survival in PTCL, not otherwise specified, but was associated with other unfavorable prognostic factors. A trend toward inferior survival for lymphopenic patients was also observed in AITL, ALK- ALCL and extranasal NKTCL lymphoma, whereas no difference in survival was found in nasal NKTCL, ALK+ ALCL, or enteropathy-associated T-cell lymphoma. In this study, lymphopenia was identified as a new adverse prognostic factor in the lymphoma type of ATLL.

AB - Lymphopenia is a marker of inferior survival in patients with various malignancies. However, the prognostic significance of lymphopenia in peripheral T-cell lymphoma (PTCL) is unclear. We analyzed the prognostic significance of lymphopenia in 826 patients with different types of PTCL and natural killer/T-cell lymphoma (NKTCL) from the International Peripheral T-cell Lymphoma Project. Lymphopenia was defined as an absolute lymphocyte count of less than 1,000 cells per microliter. The overall frequency of lymphopenia was 35.3%, ranging from 21.1% in ALK+ anaplastic large cell lymphoma (ALCL) to 47.5% in angioimmunoblastic T-cell lymphoma (AITL). Lymphopenia was independently associated with an inferior overall survival (OS) in patients with the lymphoma type of adult T-cell leukemia/lymphoma (ATLL), with a 2-year OS of 15% versus 40% for those without lymphopenia (P < 0.001). Lymphopenia was also an adverse predictor of survival in PTCL, not otherwise specified, but was associated with other unfavorable prognostic factors. A trend toward inferior survival for lymphopenic patients was also observed in AITL, ALK- ALCL and extranasal NKTCL lymphoma, whereas no difference in survival was found in nasal NKTCL, ALK+ ALCL, or enteropathy-associated T-cell lymphoma. In this study, lymphopenia was identified as a new adverse prognostic factor in the lymphoma type of ATLL.

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