The progress of the periodontal syndrome in the rice rat: II. The effects of a diphosphonate on the periodontium

Jack Gotcher, W. S.S. Jee

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Abstract

The effects of a diphosphonate, dichloromethylene diphosphonate (C12MDP) were studied using the rice rat as a model of periodontal bone loss. C12MDP was given in daily subcutaneous injections at dosages of 0 (control), 0.1, 1.0, or 10.0 mg/kg/day; these treatments were continued for periods of 6, 12, or 18 weeks. The amount of alveolar bone was increased over age matched controls at the 1.0 and 10.0 mg/kg/day doses at 6 weeks; at 12 and 18 weeks, all doses including 0.1 mg/kg/day showed increases in bone over controls. Due to increased connective tissue fibrosis, the CI2MDP treated animals had fewer vascular spaces. Also, the amount of destroyed tissue in the interdental test site was increased in animals given 10.0 mg/kg/day of C12MDP. The number of fibroblasts per mm of bone surface decreased slightly at 6 weeks, but was otherwise not different from controls in treated animals at 12 and 18 weeks. Numbers of osteoblasts decreased greatly at all doses at both 12 and 18 weeks time. There were no significant differences between treated and control animals in the number of osteoclast nuclei per mm bone surface. Also, the numbers of inflammatory cells residing at the bone surface increased at all time periods in the 10.0 mg/kg/day dose group. Finally, the proliferative activity of PDL fibroblasts decreased dramatically at all time periods in the 10.0 mg/kg/day dose group. The response of the proximal tibia to C12MDP was compared to the alveolar bone response in these animals by measuring amounts of bone in respective areas. While the dose response curves are similar, the tibiae showed greater increases in bone mass.

Original languageEnglish (US)
Pages (from-to)441-455
Number of pages15
JournalJournal of Periodontal Research
Volume16
Issue number4
DOIs
StatePublished - Jan 1 1981

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Sigmodontinae
Periodontium
Diphosphonates
Bone and Bones
Tibia
Fibroblasts
Clodronic Acid
Alveolar Bone Loss
Osteoclasts
Subcutaneous Injections
Osteoblasts
Connective Tissue
Blood Vessels
Fibrosis
Cell Count

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

The progress of the periodontal syndrome in the rice rat : II. The effects of a diphosphonate on the periodontium. / Gotcher, Jack; Jee, W. S.S.

In: Journal of Periodontal Research, Vol. 16, No. 4, 01.01.1981, p. 441-455.

Research output: Contribution to journalArticle

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