The proteomics and interactomics of human erythrocytes

Steven Goodman, Ovidiu Daescu, David G. Kakhniashvili, Marko Zivanic

Research output: Contribution to journalReview article

43 Citations (Scopus)

Abstract

In this minireview, we focus on advances in our knowledge of the human erythrocyte proteome and interactome that have occurred since our seminal review on the topic published in 2007. As will be explained, the number of unique proteins has grown from 751 in 2007 to 2289 as of today. We describe how proteomics and interactomics tools have been used to probe critical protein changes in disorders impacting the blood. The primary example used is the work done on sickle cell disease where biomarkers of severity have been identified, protein changes in the erythrocyte membranes identified, pharmacoproteomic impact of hydroxyurea studied and interactomics used to identify erythrocyte protein changes that are predicted to have the greatest impact on protein interaction networks.

Original languageEnglish (US)
Pages (from-to)509-518
Number of pages10
JournalExperimental Biology and Medicine
Volume238
Issue number5
DOIs
StatePublished - Aug 1 2013

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Proteomics
Erythrocytes
Proteins
Protein Interaction Maps
Hydroxyurea
Erythrocyte Membrane
Sickle Cell Anemia
Proteome
Biomarkers
Blood
Membranes

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

The proteomics and interactomics of human erythrocytes. / Goodman, Steven; Daescu, Ovidiu; Kakhniashvili, David G.; Zivanic, Marko.

In: Experimental Biology and Medicine, Vol. 238, No. 5, 01.08.2013, p. 509-518.

Research output: Contribution to journalReview article

Goodman, Steven ; Daescu, Ovidiu ; Kakhniashvili, David G. ; Zivanic, Marko. / The proteomics and interactomics of human erythrocytes. In: Experimental Biology and Medicine. 2013 ; Vol. 238, No. 5. pp. 509-518.
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