The Rationale for Continuous Maintenance Treatment of Reflux Esophagitis

Colin Howden, Donald O. Castell, Sidney Cohen, James W. Freston, Roy C. Orlando, Malcolm Robinson

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Reflux esophagitis is a chronic process associated with frequent episodes of relapse in many patients. In addition, the disease may be progressive in at least some patients. Erosion of the esophageal mucosa precedes the development of some of the complications of the condition. There is accumulating evidence that continuous treatment of patients with erosive esophagitis effectively maintains symptomatic remission and absence of esophageal erosions. Whether such treatment will prevent the development of complications has not yet been demonstrated. We investigated a number of questions concerning the natural history and complications of erosive esophagitis and the need for maintenance treatment for patients with severe manifestations of disease as well as the impact of continuous maintenance treatment on the natural history of reflux esophagitis and its complications.

Original languageEnglish (US)
Pages (from-to)1465-1471
Number of pages7
JournalArchives of Internal Medicine
Volume155
Issue number14
DOIs
StatePublished - Jul 24 1995

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Peptic Esophagitis
Esophagitis
Therapeutics
Natural History
Recurrence

All Science Journal Classification (ASJC) codes

  • Internal Medicine

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The Rationale for Continuous Maintenance Treatment of Reflux Esophagitis. / Howden, Colin; Castell, Donald O.; Cohen, Sidney; Freston, James W.; Orlando, Roy C.; Robinson, Malcolm.

In: Archives of Internal Medicine, Vol. 155, No. 14, 24.07.1995, p. 1465-1471.

Research output: Contribution to journalArticle

Howden, C, Castell, DO, Cohen, S, Freston, JW, Orlando, RC & Robinson, M 1995, 'The Rationale for Continuous Maintenance Treatment of Reflux Esophagitis', Archives of Internal Medicine, vol. 155, no. 14, pp. 1465-1471. https://doi.org/10.1001/archinte.1995.00430140011001
Howden, Colin ; Castell, Donald O. ; Cohen, Sidney ; Freston, James W. ; Orlando, Roy C. ; Robinson, Malcolm. / The Rationale for Continuous Maintenance Treatment of Reflux Esophagitis. In: Archives of Internal Medicine. 1995 ; Vol. 155, No. 14. pp. 1465-1471.
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